(2-Hexadecanoyloxy-3-iodopropyl) hexadecanoate

Base Information

• Chemical Name: (2-Hexadecanoyloxy-3-iodopropyl) hexadecanoate
• CAS No.: 40290-36-6
• Molecular Formula: C35H67IO4
• Molecular Weight: 678.80900
• Hs Code.: 2915900090
• DSSTox Substance ID: DTXSID60404782
• Mol file: 40290-36-6.mol

Synonyms:40290-36-6;1,2-DIPALMITOYL-3-IODO-RAC-3-DEOXYGLYCEROL;(2-hexadecanoyloxy-3-iodopropyl) hexadecanoate;1,2-Dipalmitoyl-3-iodo-3-deoxy-rac-glycerol;1,2-Dipalmitoyl-3-iododeoxy-rac-glycerol;DTXSID60404782;3-iodopropane-1,2-diyl dipalmitate;FT-0639631

Chemical Property of (2-Hexadecanoyloxy-3-iodopropyl) hexadecanoate

Chemical Property:

• PSA: 52.60000
• LogP: 11.83900
• Storage Temp.: −20°C
• XLogP3: 15.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 34
• Exact Mass: 678.40841
• Heavy Atom Count: 40
• Complexity: 540

Purity/Quality:

99%min ^*data from raw suppliers

1,2-Dipalmitoyl-3-iododeoxy-rac-glycerol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC(CI)OC(=O)CCCCCCCCCCCCCCC
• Uses: 1,2-Dipalmitoyl-3-iododeoxy-rac-glycerol is used to prepare glycolipid amphipathic micellar delivery systems for DNA and RNA biological active polyions.

Technology Process of (2-Hexadecanoyloxy-3-iodopropyl) hexadecanoate

There total 4 articles about (2-Hexadecanoyloxy-3-iodopropyl) hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-iodo-propane-1,2-diol (554-10-9) + n-hexadecanoyl chloride (112-67-4) → rac-1,2-dipalmitoyl-3-iodo-3-deoxyglycerol (40290-36-6)

Guidance literature:

Reference yield:

1,2-dipalmitoyl-sn-glycerol (30334-71-5) → rac-1,2-dipalmitoyl-3-iodo-3-deoxyglycerol (40290-36-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

3-iodo-propane-1,2-diol (554-10-9) → rac-1,2-dipalmitoyl-3-iodo-3-deoxyglycerol (40290-36-6)

Guidance literature:

With quinoline; und Behandeln mit einer Loesung von Palmitoylchlorid in Chloroform in der Kaelte;

upstream raw materials:

3-iodo-propane-1,2-diol

n-hexadecanoyl chloride

1,2-dipalmitoyl-sn-glycerol

Refernces

• 1、 -. "Liposome, preparation method, of liposome, liposome assembly and carrying liposome complex (by machine translation)". Paragraph 0216-0220. . Retrieved 2019/12/25.
• 2、 Chalabala,Lichnerova,Starha,Lukas. "Glycerin esters of some higher fatty acids as pharmaceutic aids. II. Preparation of diester and triester". . p. 277 - 278. Retrieved 2007/10/05.