H-GLY-LEU-MET-NH2 HCL

Base Information

• Chemical Name: H-GLY-LEU-MET-NH2 HCL
• CAS No.: 40297-96-9
• Molecular Formula: C13H26N4O3S.ClH
• Molecular Weight: 354.901
• Mol file: 40297-96-9.mol

Synonyms:H-Gly-Leu-Met-NH2;HCl*Gly-Leu-Met-NH2;Gly-Leu-Met-NH2*HCl;H-Gly-Leu-Met-NH2 hydrochloride;SUBSTANCE P (9-11) HCL;H-Gly-Leu-Met-NH2*HCl;HCl-H-Gly-Leu-Met-NH2;SUBSTANCE P (9-11);

Chemical Property of H-GLY-LEU-MET-NH2 HCL

Chemical Property:

• PSA: 152.61000
• LogP: 2.18360
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Substance P (9-11) > 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-GLY-LEU-MET-NH2 HCL

There total 15 articles about H-GLY-LEU-MET-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Gly-Leu-Met-NH2 (3235-59-4) → H-Gly-Leu-Met-NH2 hydrochloride (40297-96-9)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1h;

DOI:10.1021/jm00352a022

Reference yield: 81.0%

MCA-Leu-Met-OMe (75189-49-0) → H-Gly-Leu-Met-NH2 hydrochloride (40297-96-9)

Guidance literature:

With ammonia; In methanol; for 48h; Ambient temperature;

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → H-Gly-Leu-Met-NH2 hydrochloride (40297-96-9)

Guidance literature:

Multi-step reaction with 2 steps

2: 100 percent / HCl / acetic acid / 1 h

With hydrogenchloride; In acetic acid;

DOI:10.1021/jm00352a022

upstream raw materials:

Boc-Gly-Leu-Met-NH₂

MCA-Leu-Met-OMe

N-tert-butoxycarbonyl-L-leucine

N-chloroacetyl-L-leucine

Downstream raw materials:

N-t-Boc-Phe-Phe-Gly-Leu-Met-NH₂

Boc-Phe-Gly-Leu-Met-NH₂

pGlu-gPhe-(RS)-mPhe-Gly-Leu-Met-NH₂

t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

Refernces

• 1、 Chorev,Yaion,Wormser,et al.. "Partially modified retro-inverso peptides analogs: [pGlu6, Phe7ψ(NH-CO)Phe8]substance P (6-11), synthesis and biological activity". . p. 96 - 102. Retrieved 2007/10/02.
• 2、 Kuhl, Peter,Doering, Guenter,Neubert, Klaus,Jakubke, Hans-Dieter. "Synthesis of N-Protected Eledoisin (6-11)-hexapeptide Using Proteases as Biocatalysts". . p. 423 - 430. Retrieved 2007/10/02.