Technology Process of (2R,3S)-3-methyl-2-phenyl-2,3-dihydrofuran
There total 6 articles about (2R,3S)-3-methyl-2-phenyl-2,3-dihydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper diacetate; triethylamine;
In
dichloromethane;
at 20 ℃;
for 22h;
Inert atmosphere;
DOI:10.1021/jacs.7b06408
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran;
for 1h;
Reflux;
DOI:10.1021/jacs.5b08019
- Guidance literature:
-
Multi-step reaction with 2 steps
1: carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); (R)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; tetra-(n-butyl)ammonium iodide; 2,4,6-tri(iso-propyl)benzenesulfonic acid / tetrahydrofuran / 85 °C
2: tetrabutyl ammonium fluoride; triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / Reflux
With
carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); 2,4,6-tri(iso-propyl)benzenesulfonic acid; (R)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran;
DOI:10.1021/jacs.5b08019