2,5-Pyrrolidinedione, 1-[3-(methyldithio)-1-oxopropoxy]-

Base Information

• Chemical Name: 2,5-Pyrrolidinedione, 1-[3-(methyldithio)-1-oxopropoxy]-
• CAS No.: 403518-14-9
• Molecular Formula: C₈H₁₁NO₄S₂
• Molecular Weight: 249.312
• Mol file: 403518-14-9.mol

Synonyms:3-methyldisulfanylpropionic acid 2,5-dioxopyrrolidin-1-yl ester;

Chemical Property of 2,5-Pyrrolidinedione, 1-[3-(methyldithio)-1-oxopropoxy]-

Chemical Property:

• PSA: 114.28000
• LogP: 0.93280

Purity/Quality:

1-[3-(Methyldithio)-1-oxopropoxy]-2,5-pyrrolidinedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-[3-(Methyldithio)-1-oxopropoxy]-2,5-pyrrolidinedione is an intermediate used in the synthesis of Mertansine-13CD3 (M257802), which is the isotope labelled analog of Mertansine (M257800); a cytotoxic agent used as the cytotoxic component in antibody-drug conjugates.

Technology Process of 2,5-Pyrrolidinedione, 1-[3-(methyldithio)-1-oxopropoxy]-

There total 1 articles about 2,5-Pyrrolidinedione, 1-[3-(methyldithio)-1-oxopropoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-Methyldisulfanyl-propionic acid (138148-59-1) → 3-(methyldisulfanyl)propanoic acid N-hydroxysuccinimide ester (403518-14-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h;

DOI:10.1021/jm060319f

Reference yield:

3-(methyldisulfanyl)propanoic acid N-hydroxysuccinimide ester (403518-14-9) + [3H]-Vedotin (474645-27-7,1057314-02-9) → C43H73N5O8S2

Guidance literature:

In aq. phosphate buffer; acetonitrile; at 20 ℃; for 48h; pH=7.5;

DOI:10.1039/c6ob01751g

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-Methyldisulfanyl-propionic acid

Refernces

• 1、 -. "VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES". Page/Page column 75-76. . Retrieved 2021/07/24.
• 2、 Tang, Feng,Yang, Yang,Tang, Yubo,Tang, Shuai,Yang, Liyun,Sun, Bingyang,Jiang, Bofeng,Dong, Jinhua,Liu, Hong,Huang, Min,Geng, Mei-Yu,Huang, Wei. "One-pot: N -glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates". supporting information. p. 9501 - 9518. Retrieved 2016/10/22.