7-DEAZA-2'-DEOXYGUANOSINE

Base Information

• Chemical Name: 7-DEAZA-2'-DEOXYGUANOSINE
• CAS No.: 86392-75-8
• Molecular Formula: C₁₁H₁₄N₄O₄
• Molecular Weight: 266.257
• Mol file: 86392-75-8.mol

Synonyms:7-Deaza-2'-deoxyguanosine;98: PN: US20050130918 PAGE: 60 claimed sequence

Chemical Property of 7-DEAZA-2'-DEOXYGUANOSINE

Chemical Property:

• Vapor Pressure: 2.64E-16mmHg at 25°C
• Melting Point: 262-265 °C
• Boiling Point: 621.4 ºC at 760 mmHg
• PKA: 11.29±0.20(Predicted)
• Flash Point: 329.6 ºC
• PSA: 126.39000
• Density: 1.9 g/cm³
• LogP: -0.47130
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%, ^*data from raw suppliers

7-Deaza-2?-deoxyguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-DEAZA-2'-DEOXYGUANOSINE

There total 14 articles about 7-DEAZA-2'-DEOXYGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-methoxyl-7H-pyrrolo[2,3-d]pyrimidine (86392-74-7) → 7-deaza-2'-deoxyguanosine (86392-75-8)

Guidance literature:

With trimethylsilyl iodide;

DOI:10.1016/S0040-4039(00)95603-X

Reference yield: 90.0%

2-amino-4-butoxy-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine (115945-79-4) → 7-deaza-2'-deoxyguanosine (86392-75-8)

Guidance literature:

With sodium hydroxide; for 4h; Heating;

DOI:10.1039/P19880000697

Reference yield: 86.0%

2-amino-7-<2-deoxy-β-D-erythro-pentofuranosyl>-4-isobutoxy-7H-pyrrolo<2,3-d>pyrimidine (115945-80-7) → 7-deaza-2'-deoxyguanosine (86392-75-8)

Guidance literature:

With sodium hydroxide; for 4h; Heating;

DOI:10.1039/P19880000697

upstream raw materials:

2-amino-4-chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

2-Amino-7-<2-desoxy-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-thion

2-amino-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-methoxyl-7H-pyrrolo[2,3-d]pyrimidine

2-amino-7-<2-deoxy-β-D-erythro-pentofuranosyl>-4-isobutoxy-7H-pyrrolo<2,3-d>pyrimidine

Downstream raw materials:

7-(2-Desoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl)-2-<(4,4'-dimethoxytriphenylmethyl)amino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on

2-amino-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4(3H)-one

7-(2,3-Didesoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-glycero-pentofuranosyl)-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on

7-<2-Desoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-2-<(dimethylamino)methylenamino>-3,7-dihydro-4H-pyrrolo<2,3-d>pyrimidin-4-on

Refernces

• 1、 -. "Enhanced triple-helix and double-helix formation with oligomers containing modified purines". . . Retrieved 2008/06/13.
• 2、 Ramasamy,Imamura,Robins,Revankar. "A facile and improved synthesis of tubercidin and certain related pyrrolo[2,3-d]pyrimidine nucleosides by the stereospecific sodium salt glycosylation procedure [1]". . p. 1893 - 1898. Retrieved 2007/10/02.