p-Hydroxy-N-methylbenzenesulfonamide

Base Information

• Chemical Name: p-Hydroxy-N-methylbenzenesulfonamide
• CAS No.: 3077-61-0
• Molecular Formula: C7H9 N O3 S
• Molecular Weight: 187.219
• Hs Code.: 2935009090
• Mol file: 3077-61-0.mol

Synonyms:Benzenesulfonamide,p-hydroxy-N-methyl- (7CI,8CI); N-Methyl-1-phenol-4-sulfonamide

Chemical Property of p-Hydroxy-N-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.67E-05mmHg at 25°C
• Boiling Point: 354.2°Cat760mmHg
• Flash Point: 168°C
• PSA: 74.78000
• Density: 1.352g/cm³
• LogP: 1.77200

Purity/Quality:

4-Hydroxy-N-methylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Hydroxy-N-methylbenzenesulfonamide

There total 5 articles about p-Hydroxy-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-hydroxybenzenesulphonamide (1576-43-8) + bis(1-methyl-1-phenylethyl)peroxide (80-43-3) → 4-hydroxy-N-methylbenzenesulfonamide (3077-61-0)

Guidance literature:

With copper acetylacetonate; In acetone; at 120 ℃; for 8h; Sealed tube;

DOI:10.1080/00397911.2020.1859118

Reference yield:

4-benzoyloxybenzenesulfonyl chloride (89820-22-4) + methylamine (74-89-5) → 4-hydroxy-N-methylbenzenesulfonamide (3077-61-0)

Guidance literature:

With diethyl ether; Behandeln des Reaktionsprodukts mit wss. HCl;

DOI:10.1021/jm00327a020

Reference yield:

4-hydroxybenzene-1-sulfonyl fluoride (368-87-6) + methylamine (74-89-5) → 4-hydroxy-N-methylbenzenesulfonamide (3077-61-0)

Guidance literature:

With ethanol; at 40 ℃;

upstream raw materials:

4-hydroxybenzene-1-sulfonyl fluoride

methylamine

4-benzoyloxybenzenesulfonyl chloride

4-hydroxybenzenesulphonamide

Downstream raw materials:

2,6-Dibromo-N-methyl-1-phenol-4-sulfonamide

C₁₂H₁₉N₂O₄PS₂

Refernces

• 1、 -. "Angiotensin II antagonists". . . Retrieved 2008/06/13.
• 2、 -. "Angiotensin II antagonists". . . Retrieved 2008/06/13.