DIETHYL-2-FLUORO OXALOACETATE

Base Information

• Chemical Name: DIETHYL-2-FLUORO OXALOACETATE
• CAS No.: 407-27-2
• Molecular Formula: C8H13FO4
• Molecular Weight: 192.18500
• Mol file: 407-27-2.mol

Synonyms:2-Fluor-bernsteinsaeure-diethylester;Fluor-bernsteinsaeure-diaethylester;Diethyl-fluorsuccinat;DIETHYL-2-FLUORO OXALOACETATE;

Chemical Property of DIETHYL-2-FLUORO OXALOACETATE

Chemical Property:

• PSA: 52.60000
• LogP: 0.84080

Purity/Quality:

98%Min ^*data from raw suppliers

FLUORO-BUTANEDIOIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL-2-FLUORO OXALOACETATE

There total 8 articles about DIETHYL-2-FLUORO OXALOACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Potassium; (E)-1,2,3-tris-ethoxycarbonyl-propen-1-olate → 2-Fluor-bernsteinsaeure-diethylester (407-27-2)

Guidance literature:

With perchloryl fluoride; In ethanol;

DOI:10.1021/jo01014a051

Reference yield:

2-Fluoro-2-nitro-succinic acid diethyl ester (110683-77-7) → 2-Fluor-bernsteinsaeure-diethylester (407-27-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2h; Heating;

DOI:10.1021/jo00231a053

Reference yield:

diethyl (RS)-nitrosuccinate (70683-11-3) → 2-Fluor-bernsteinsaeure-diethylester (407-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / KF, perchloryl fluoride / tetrahydrofuran / 1 h / 22 °C

2: n-Bu₃SnH, AIBN / benzene / 2 h / Heating

With potassium fluoride; perchloryl fluoride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; benzene;

DOI:10.1021/jo00231a053

upstream raw materials:

ethyl 2-fluoroacetate

sodium ethanolate

ethyl bromoacetate

DL-aspartic acid diethyl ester

Refernces

• 1、 Takeuchi, Yoshio,Nagata, Kazuhiro,Koizumi, Toru. "The First Versatile and Practical Building Blocks Equivalent to the Synthon of Monofluoromethylene Dicarbanion". . p. 5061 - 5063. Retrieved 2007/10/02.
• 2、 Hamman, Sylvain,Beguin, Claude,Charlon, Claude,Luu-Duc, Cuong. "Conformational Studies on 2-Fluoro-1,2-disubstituted Ethanes by NMR Spectroscopy. Influence of Electronegativity on Vicinal Proton-Proton and Fluorine-Proton Coupling Constants". . p. 361 - 366. Retrieved 2007/10/02.