8-hydroxycarvotanacetone

Base Information

• Chemical Name: 8-hydroxycarvotanacetone
• CAS No.: 7712-46-1
• Molecular Formula: C10H16 O2
• Molecular Weight: 168.236
• Mol file: 7712-46-1.mol

Synonyms:p-Menth-6-en-2-one,8-hydroxy- (6CI,7CI,8CI);2-Methyl-5-(1-hydroxy-1-methylethyl)-2-cyclohexen-1-one; 2-Methyl-5-(a-methyl-a-hydroxyethyl)cyclohex-2-en-1-one;5-(1-Hydroxy-1-methylethyl)-2-methylcyclohex-2-en-1-one;8-Hydroxy-p-menth-6-en-2-one; 8-Hydroxycarvotanacetone; Carvone hydrate; HCA168

Chemical Property of 8-hydroxycarvotanacetone

Chemical Property:

• PSA: 37.30000
• LogP: 1.68270

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-hydroxycarvotanacetone

There total 29 articles about 8-hydroxycarvotanacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trans-Sobrerol (454-77-3,498-71-5,772-36-1,32226-54-3,38235-58-4,42370-41-2,54164-89-5,60687-00-5,71697-84-2) → 5-(1-Hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enone (7712-46-1)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; bathophenanthroline; caesium carbonate; copper(l) chloride; In toluene; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2012.08.095

Reference yield: 89.0%

→ 5-(1-Hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enone (7712-46-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h;

Reference yield: 85.0%

trans-sobrerol (32226-54-3) → 5-(1-Hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enone (7712-46-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1002/hlca.19870700109

upstream raw materials:

terpineol

(S)-p-mentha-6,8-dien-2-one

2-methyl-5-(1-methyl-1-oxiranyl)-2-cyclohexen-1-one

trans-sobrerol

Downstream raw materials:

trans-sobrerol

1(S)-5(S)-(+)-cis-sobrerol

(+/-)-4,7,7-trimethyl-6-oxabicyclo<3.2.1>oct-3-ene

carvacrol

Refernces

• 1、 Nishii, Takeshi,Ouchi, Tomomi,Matsuda, Aya,Matsubara, Yuka,Haraguchi, Yuuko,Kawano, Tomomi,Kaku, Hiroto,Horikawa, Mitsuyo,Tsunoda, Tetsuto. "Modified Marko's aerobic oxidation of alcohols under atmospheric pressure with air or molecular oxygen at room temperature". . p. 5880 - 5882,3. Retrieved 2020/07/31.
• 2、 Mandal, Sunil K.,Jensen, David R.,Pugsley, Jacob S.,Sigman, Matthew S.. "Scope of enantioselective Palladium(II)-catalyzed aerobic alcohol oxidations with (-)-sparteine". . p. 4600 - 4603. Retrieved 2007/10/03.