sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate

Base Information

• Chemical Name: sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
• CAS No.: 41733-55-5
• Molecular Formula: C12H11ClN2O5S.Na
• Molecular Weight: 352.731
• Hs Code.: 2935009090
• Mol file: 41733-55-5.mol

Synonyms:Frosemide sodium;sodium 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoate;54-31-9 (Parent);UNII-101EM454S7;Sodium furosemide;Furosemide sodium;

Chemical Property of sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate

Chemical Property:

• Vapor Pressure: 2.15E-14mmHg at 25°C
• Melting Point: 206oC
• Boiling Point: 582.1oC at 760 mmHg
• Flash Point: 305.9oC
• PSA: 133.84000
• LogP: 2.41010

Purity/Quality:

99.9% ^*data from raw suppliers

Furosemidesodium 99.69% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate

There total 2 articles about sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furan-2-ylmethanamine (617-89-0) + 2,4-dichloro-5-sulfonamide sodium benzoate → 4-chloro-N-(2-furfuryl)-5-sulfamoylanthranilic acid sodium salt (41733-55-5)

Guidance literature:

In ethylene glycol; at 130 - 135 ℃; for 3h; Solvent;

Reference yield:

2,4-dichloro-5-sulfamoylbenzoic acid (2736-23-4) → 4-chloro-N-(2-furfuryl)-5-sulfamoylanthranilic acid sodium salt (41733-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate; pyrographite / ethanol / 2 h / 40 °C

2: ethylene glycol / 3 h / 130 - 135 °C

With sodium ethanolate; pyrographite; In ethanol; ethylene glycol;

Reference yield: 53.0%

zinc perchlorate + tris(N-methylbenzimidazol-2-ylmethyl)amine (82137-72-2) + 4-chloro-N-(2-furfuryl)-5-sulfamoylanthranilic acid sodium salt (41733-55-5) → [(N(CH2(C7H4N2(CH3)))3)ZnOCOC6H2(SO2NH2)(NHCH2C4H3O)(Cl)](1+)*ClO4(1-)*CH2Cl2 = C39H37Cl2N9O9SZn*CH2Cl2 (159665-36-8)

Guidance literature:

In methanol; dichloromethane; water; stirred for 4 days; concd. in vacuo; stored for 5 days at -25°C, ppt. washed (cold MeOH), dried in vacuo; elem. anal.;

upstream raw materials:

2,4-dichloro-5-sulfamoylbenzoic acid

furan-2-ylmethanamine

Downstream raw materials:

[(N(CH₂(C₇H₄N₂(CH₃)))3)ZnOCOC₆H₂(SO₂NH₂)(NHCH₂C₄H₃O)(Cl)]⁽¹⁺⁾*ClO₄^(1-)*CH₂Cl₂ = C₃₉H₃₇Cl₂N₉O₉SZn*CH₂Cl₂

4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid

Refernces