1-PHENYL-3-CHLORO-1-PROPYNE

Base Information

• Chemical Name: 1-PHENYL-3-CHLORO-1-PROPYNE
• CAS No.: 3355-31-5
• Molecular Formula: C9H7Cl
• Molecular Weight: 150.608
• Hs Code.: 2901100000
• Mol file: 3355-31-5.mol

Synonyms:Propyne, 3-chloro-1-phenyl- (6CI,7CI);(3-Chloro-1-propyn-1-yl)benzene;1-Chloro-3-phenyl-2-propyne;3-Chloro-1-phenyl-1-propyne;3-Phenylpropargylchloride;Chloromethyl(phenyl)acetylene;NSC 147127;Phenylpropargyl chloride;

Chemical Property of 1-PHENYL-3-CHLORO-1-PROPYNE

Chemical Property:

• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 221.04 °C at 760 mmHg
• Flash Point: 82.851 °C
• PSA: 0.00000
• Density: 1.123 g/cm³
• LogP: 2.27690
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-1-phenyl-1-propyne 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Chloro-1-phenyl-1-propyne is used as an organic chemical synthesis intermediate.

Technology Process of 1-PHENYL-3-CHLORO-1-PROPYNE

There total 11 articles about 1-PHENYL-3-CHLORO-1-PROPYNE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-Phenyl-2-propyn-1-ol (1504-58-1) → 1-chloro-3-phenyl-2-propyne (3355-31-5)

Guidance literature:

With oxalyl dichloride; 2,3-bis(4-methoxyphenyl)cyclopropenone; In dichloromethane; at 30 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201104638

Reference yield: 42.0%

C16H17ClN2O2S → 1-chloro-3-phenyl-2-propyne (3355-31-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; oxygen; copper(l) chloride; In dimethyl sulfoxide; at 100 ℃; for 12h; under 760.051 Torr; regioselective reaction; Schlenk technique;

DOI:10.1002/anie.201405058

Reference yield:

3-Phenyl-2-propyn-1-ol (1504-58-1) + p-toluenesulfonyl chloride (98-59-9) → 1-chloro-3-phenyl-2-propyne (3355-31-5)

Guidance literature:

With pyridine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

3-Phenyl-2-propyn-1-ol

formaldehyd

phenylacetylene

C₁₅H₁₂Cl₂Se

Downstream raw materials:

2,5-di(3-phenyl-2-propynylthio)-1,3,4-thiadiazole

diphenyl-(3-phenyl-prop-2-ynyl)-phosphine

1-Phenethyl-4-[(3-phenyl-2-propynyloxy)-ethyl] piperidine, hydrochloride salt

cis-[Pt(η(1)-CH2CCPh)(Cl)(PPh3)2]

Refernces

• 1、 Li, Xianwei,Liu, Xiaohang,Chen, Huoji,Wu, Wanqing,Qi, Chaorong,Jiang, Huanfeng. "Copper-catalyzed aerobic oxidative transformation of ketone- Derived N-tosyl hydrazones: An entry to alkynes". supporting information. p. 14485 - 14489. Retrieved 2015/02/05.
• 2、 Miyake, Yoshihiro,Ota, Shin-Ichi,Shibata, Masashi,Nakajima, Kazunari,Nishibayashi, Yoshiaki. "Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides". supporting information. p. 7809 - 7811. Retrieved 2013/09/02.