3-Piperidinecarboxylic acid, 1-benzoyl-4-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Piperidinecarboxylic acid, 1-benzoyl-4-oxo-, ethyl ester
• CAS No.: 4451-86-9
• Molecular Formula: C15H17NO4
• Molecular Weight: 275.304
• Mol file: 4451-86-9.mol

Synonyms:ethyl-1-benzoyl-4-oxo-3-piperidine carboxylate;1-benzoyl-4-oxo-piperidine-3-carboxylic acid ethyl ester;1-Benzoyl-4-oxo-piperidin-3-carbonsaeure-ethylester;ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate;1-Benzoyl-4-oxo-piperidin-3-carbonsaeure-aethylester;ethyl N-benzoyl-4-piperidone-3-carboxylate;

Chemical Property of 3-Piperidinecarboxylic acid, 1-benzoyl-4-oxo-, ethyl ester

Chemical Property:

• PSA: 63.68000
• LogP: 1.21880

Purity/Quality:

95% ^*data from raw suppliers

Ethyl1-benzoyl-4-oxopiperidine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 1-benzoyl-4-oxo-, ethyl ester

There total 6 articles about 3-Piperidinecarboxylic acid, 1-benzoyl-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 4-piperidone-3-carboxylate hydrochloride (4644-61-5) + benzoyl chloride (98-88-4) → ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate (4451-86-9)

Guidance literature:

With sodium hydroxide; In chloroform; water; at 0 ℃; for 2h;

Reference yield: 34.0%

benzamide (55-21-0,27208-38-4) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate (4451-86-9)

Guidance literature:

With sodium hydride; In toluene; at 60 ℃; for 24h;

DOI:10.1016/S0223-5234(99)80046-4

Reference yield:

3,3'-benzoylimino-di-propionic acid diethyl ester (101599-56-8) → ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate (4451-86-9)

Guidance literature:

With ethanol; sodium; benzene;

DOI:10.1021/ja01210a040

upstream raw materials:

3,3'-benzoylimino-di-propionic acid diethyl ester

ethyl 4-piperidone-3-carboxylate hydrochloride

benzoyl chloride

benzamide

Downstream raw materials:

8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane-6-carboxylic acid ethyl ester

ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate

ethyl-1-benzoyl-4-oxo-3-(2-propenyl)-3-piperidine carboxylate

8-benzoyl-1,4-dioxa-8-aza-spiro[4.5]decane-6-carbonitrile

Refernces

• 1、 -. "Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same". . . Retrieved 2008/06/13.
• 2、 McHugh, Michael,Proctor, George R.. "Ring-expansion of some heterocyclic β-ketoesters with dimethyl acetylene dicarboxylate. Part 2". . p. 2230 - 2253. Retrieved 2007/10/02.