Azetidine, 1-(4-fluorobenzoyl)-

Base Information

• Chemical Name: Azetidine, 1-(4-fluorobenzoyl)-
• CAS No.: 446313-52-6
• Molecular Formula: C10H10FNO
• Molecular Weight: 179.194
• Mol file: 446313-52-6.mol

Synonyms:

Chemical Property of Azetidine, 1-(4-fluorobenzoyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Azetidine, 1-(4-fluorobenzoyl)-

There total 2 articles about Azetidine, 1-(4-fluorobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzoyl chloride (403-43-0) + azetidine hydrochloride (78797-58-7,78797-59-8,78797-62-3,36520-39-5,65546-09-0) → azetidin-1-yl(4-fluorophenyl)methanone (446313-52-6)

Guidance literature:

With potassium carbonate; In diethyl ether; water; at -78 - 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00842

Reference yield:

→ azetidin-1-yl(4-fluorophenyl)methanone (446313-52-6)

Guidance literature:

Reference yield: 81.0%

azetidin-1-yl(4-fluorophenyl)methanone (446313-52-6) + phenyllithium (591-51-5) → 4-fluorobenzophenone (345-83-5)

Guidance literature:

In tetrahydrofuran; dibutyl ether; at -78 ℃; for 0.25h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b00842

upstream raw materials:

4-fluorobenzoyl chloride

azetidine hydrochloride

Downstream raw materials:

4-fluorobenzophenone

Refernces

• 1、 -. "SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS". Page/Page column 30. . Retrieved 2010/02/10.