1-(3-broMophenyl)-2,2,2-trifluoroethanol

Base Information

• Chemical Name: 1-(3-broMophenyl)-2,2,2-trifluoroethanol
• CAS No.: 446-63-9
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.034
• Mol file: 446-63-9.mol

Synonyms:Trifluormethyl-<3-brom-phenyl>-carbinol;1-(3-bromophenyl)-2,2,2-trifluoroethan-1-ol;<3-Brom-phenyl>-trifluormethyl-carbinol;

Chemical Property of 1-(3-broMophenyl)-2,2,2-trifluoroethanol

Chemical Property:

• PSA: 20.23000
• LogP: 3.04480
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(3-Bromophenyl)-2,2,2-trifluoroethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-broMophenyl)-2,2,2-trifluoroethanol

There total 3 articles about 1-(3-broMophenyl)-2,2,2-trifluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

m-bromobenzoic aldehyde (3132-99-8) + (trifluoromethyl)trimethylsilane (81290-20-2) → (±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol (446-63-9,1188286-64-7)

Guidance literature:

m-bromobenzoic aldehyde; (trifluoromethyl)trimethylsilane; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With water; In N,N-dimethyl-formamide; for 4h; Acidic conditions;

DOI:10.1016/j.tetlet.2013.06.045

Reference yield: 89.0%

m-bromotrifluoroacetone (655-26-5) → (±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol (446-63-9,1188286-64-7)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1139/v97-017

Reference yield:

2,2,2-trifluoroethyl trifluoroacetate (407-38-5) + 1-Bromo-3-iodobenzene (591-18-4) → (±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol (446-63-9,1188286-64-7) + m-bromotrifluoroacetone (655-26-5)

Guidance literature:

1-Bromo-3-iodobenzene; With TurboGrignard; toluene; In tetrahydrofuran; at -15 ℃; for 0.416667h; Inert atmosphere;

2,2,2-trifluoroethyl trifluoroacetate; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/ejoc.202000550

upstream raw materials:

m-bromotrifluoroacetone

m-bromobenzoic aldehyde

(trifluoromethyl)trimethylsilane

2,2,2-trifluoroethyl trifluoroacetate

Downstream raw materials:

m-bromo-1,2,2-trifluorostyrene

m-bromotrifluoroacetone

Refernces

• 1、 Kani, Ryunosuke,Inuzuka, Toshiyasu,Kubota, Yasuhiro,Funabiki, Kazumasa. "One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols". supporting information. p. 4487 - 4493. Retrieved 2020/06/01.
• 2、 -. "METALLOENZYME INHIBITOR COMPOUNDS". Page/Page column 293. . Retrieved 2017/07/31.