2-Acetylbenzimidazole

Base Information

• Chemical Name: 2-Acetylbenzimidazole
• CAS No.: 939-70-8
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• Mol file: 939-70-8.mol

Synonyms:Ketone,2-benzimidazolyl methyl (7CI,8CI);1-(1H-Benzimidazol-2-yl)ethanone;2-Acetyl-1H-benzimidazole;2-Benzimidazolyl methylketone;

Chemical Property of 2-Acetylbenzimidazole

Chemical Property:

• Vapor Pressure: 5.4E-05mmHg at 25°C
• Melting Point: 238-240
• Refractive Index: 1.658
• Boiling Point: 347.4 °C at 760 mmHg
• PKA: 10.46±0.10(Predicted)
• Flash Point: 168 °C
• PSA: 45.75000
• Density: 1.265 g/cm³
• LogP: 1.76550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Acetylbenzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Acetylbenzimidazole

There total 2 articles about 2-Acetylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiabendazole (148-79-8,98002-42-7) → benzoimidazole (51-17-2,79351-71-6) + 1H-benzo[d]imidazole-2-carboxamide (5805-52-7) + 2-acetylbenzimidazole (939-70-8)

Guidance literature:

With cucurbit[8]uril; In water; pH=1.2; Irradiation;

DOI:10.1039/c3pp50336d

Reference yield:

2-benzimidazolecarboxylic acid (2849-93-6) → 2-acetylbenzimidazole (939-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran; diethyl ether / 2.25 h / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield: 95.0%

4-methoxy-benzaldehyde (123-11-5) + 2-acetylbenzimidazole (939-70-8) → (E)-1-(1H-benzo[d]imidazol-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one (515824-31-4)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.3390/molecules24183259

upstream raw materials:

thiabendazole

2-benzimidazolecarboxylic acid

Downstream raw materials:

1-(2-benzimidazolyl)-3-phenyl-5-(2-thienyl)pentane-1,5-dione

1-(1H-benzimidazol-2-yl)-3-(p-tolyl)-2-propen-1-one

1-(1H-benzo[d]imidazol-2-yl)-3-(4-chlorophenyl)prop-2-en-1-one

1-(1H-benzo[d]imidazol-2-yl)-3-phenylprop-2-en-1-one

Refernces

• 1、 Smitka, Jaroslav,Lemos, Americo,Porel, Mintu,Jockusch, Steffen,Belderrain, Tomas R.,Tesarova, Eva,Da Silva, Jose P.. "Phototransformation of benzimidazole and thiabendazole inside cucurbit[8]uril". . p. 310 - 315. Retrieved 2014/02/14.