Benzenepropanoic acid fluoride

Base Information

• Chemical Name: Benzenepropanoic acid fluoride
• CAS No.: 458-69-5
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Mol file: 458-69-5.mol

Synonyms:Phenylpropionsaeurefluorid;3-phenylpropionyl fluoride;β-Phenylpropionsaeurefluorid;3-Phenyl-propionylfluorid;Hydrozimtsaeurefluorid;3-phenyl-propionyl fluoride;

Chemical Property of Benzenepropanoic acid fluoride

Chemical Property:

• PSA: 17.07000
• LogP: 2.11530

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid fluoride

There total 31 articles about Benzenepropanoic acid fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-Phenylpropionic acid (501-52-0) → 3-phenylpropanoic acid fluoride (458-69-5)

Guidance literature:

With triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol902039q

Reference yield: 88.0%

4-hydroxyphenyl 3-phenylpropanate (69932-21-4) → 3-phenylpropanoic acid fluoride (458-69-5)

Guidance literature:

With pyridinium polyhydrogenfluoride; bis(tertbutylcarbonyloxy)iodobenzene; In acetonitrile; at 0 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1039/d0gc03912h

Reference yield: 79.0%

hydrocinnamic acid chloride (645-45-4) → 3-phenylpropanoic acid fluoride (458-69-5)

Guidance literature:

With potassium hydrogenfluoride; tetrabutyl-ammonium chloride; water; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/a-1649-5460

upstream raw materials:

3-Phenylpropionic acid

3-phenyl-propionaldehyde

Hexafluorobenzene

S-(4-methoxyphenyl) 3-phenylpropanethioate

Downstream raw materials:

S-(p-tolyl) 3-phenylpropanethioathe

3-phenyl-1-pyrrolidin-1-yl-propane-1-one

N-(3-phenylpropanoyl)glycine methyl ester

3-(1-oxo-3-phenylpropyl)-1,3-oxazolidin-2-one

Refernces

• 1、 Ishida, Naoyoshi,Iwamoto, Hiroaki,Sunagawa, Denise Eimi,Ohashi, Masato,Ogoshi, Sensuke. "CsF-Catalyzed Fluoroacylation of Tetrafluoroethylene Using Acyl Fluorides for the Synthesis of Pentafluoroethyl Ketones". supporting information. p. 3137 - 3143. Retrieved 2020/11/13.
• 2、 He, Bangyue,Liu, Xiaojie,Li, Hongyi,Zhang, Xiaofeng,Ren, Yuxi,Su, Weiping. "Rh-Catalyzed General Method for Directed C-H Functionalization via Decarbonylation of in-Situ-Generated Acid Fluorides from Carboxylic Acids". supporting information. p. 4191 - 4196. Retrieved 2021/05/26.