(R)-(-)-1-Cyclohexylethylamine

Base Information

• Chemical Name: (R)-(-)-1-Cyclohexylethylamine
• CAS No.: 5913-13-3
• Molecular Formula: C8H17N
• Molecular Weight: 127.23
• Hs Code.: 2921300090
• European Community (EC) Number: 227-634-2
• Nikkaji Number: J58.886E
• ChEMBL ID: CHEMBL19290
• Mol file: 5913-13-3.mol

Synonyms:(R)-(-)-1-Cyclohexylethylamine;5913-13-3;(R)-1-cyclohexylethylamine;(1R)-1-cyclohexylethanamine;(r)-1-cyclohexylethan-1-amine;(R)-1-Cyclohexylethanamine;CHEMBL19290;MFCD00043338;1-Cyclohexylethanamine #;R-(-)-Cyclohexylethylamine;(R)-alpha-Cyclohexanemethylamine;(1R)-1-cyclohexylethylamine;EINECS 227-634-2;(1R)-1-cyclohexylethan-1-amine;Cyclohexanemethanamine, .alpha.-methyl-, (R)-;SCHEMBL56860;(R)-1-cyclohexyl-ethylamine;(r)-1-cyclohexyl ethyl amine;(1R)-1-cyclohexyl-ethylamine;(1R)-1-Cyclohexyl-1-ethylamine;(1R)-1-amino-1-cyclohexylethane;BDBM50028631;(S)-(+)-(1-Aminoethyl)cyclohexane;AKOS006340927;AKOS015840763;( poundO)-(-)-1-Cyclohexylethylamine;AM81440;(R)-(-)-1-Cyclohexylethylamine, 98%;AS-41202;(alphaR)-alpha-methylcyclohexanemethanamine;(R)-(-)-alpha-Methylcyclohexanemethylamine;CS-0136581;EN300-98887;A901072;(R)-(-)-1-Cyclohexylethylamine, ChiPros(R), produced by BASF, 99%;(R)-(-)-1-Cyclohexylethylamine, purum, >=98.0% (sum of enantiomers, GC)

Chemical Property of (R)-(-)-1-Cyclohexylethylamine

Chemical Property:

• Vapor Pressure: 1.2mmHg at 25°C
• Melting Point: -15°C (estimate)
• Refractive Index: n20/D 1.463
• Boiling Point: 174.6 °C at 760 mmHg
• PKA: 10.89±0.29(Predicted)
• Flash Point: 52.2 °C
• PSA: 26.02000
• Density: 0.873 g/cm³
• LogP: 2.61420
• Sensitive.: Air Sensitive
• Water Solubility.: Miscible with acetone, chloroform,dimethyl sulfoxide, ethanol, methanol, ether, petroleum ether and dichloromethane. Insoluble i
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 127.136099547
• Heavy Atom Count: 9
• Complexity: 74.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(-)-1-Cyclohexylethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-21/22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C1CCCCC1)N
• Isomeric SMILES: C[C@H](C1CCCCC1)N
• Uses: (R)-(-)-1-Cyclohexylethylamine is used in the preparation of benzylidene(1-cyclohexylethyl)amine by reacting with benzaldehyde. It is also used to prepare chiral polymethacrylamides, which are employed as stationary phases for the liquid-chromatographic resolution of racemic amides. In addition to this, it is used in the preparation of polyamides bound to silica gel for high performance liquid chromatography, which are pressure-stable. (R)-(-)-1-Cyclohexylethylamine may be used in the preparation of a chiral calix[4]arene Schiff base derivatives with potential enantioselective recognition ability towards amines.

Technology Process of (R)-(-)-1-Cyclohexylethylamine

There total 37 articles about (R)-(-)-1-Cyclohexylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-N-((R)-1-cyclohexylethyl)-2-methylpropane-2-sulfinamide → [(1R)-1-cyclohexylethyl]amine (5913-13-3)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0338

Reference yield: 96.0%

[(1S)-1-cyclohexylethyl]amine (17430-98-7) → [(1R)-1-cyclohexylethyl]amine (5913-13-3)

Guidance literature:

With nickel; at 110 ℃; for 2h; Reagent/catalyst; Time; Inert atmosphere;

DOI:10.1002/ejic.201300074

Reference yield: 93.0%

C12H23NOS → [(1R)-1-cyclohexylethyl]amine (5913-13-3)

Guidance literature:

C₁₂H₂₃NOS; With [RhCl₂(p-cymene)]2; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; at 50 ℃; for 0.5h; Inert atmosphere; Microwave irradiation; Molecular sieve;

With hydrogenchloride; In methanol; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201402884

upstream raw materials:

rac-methylbenzylamine

ammonium formate

Cyclohexyl methyl ketone

N-α-phenylethylacetamide

Refernces

• 1、 Antil, Neha,Kumar, Ajay,Akhtar, Naved,Begum, Wahida,Chauhan, Manav,Newar, Rajashree,Rawat, Manhar Singh,Manna, Kuntal. "Chemoselective and Tandem Reduction of Arenes Using a Metal–Organic Framework-Supported Single-Site Cobalt Catalyst". supporting information. p. 1031 - 1040. Retrieved 2022/01/19.
• 2、 Ernst, Martin,Ghosh, Tamal,Hashmi, A. Stephen K.,Schaub, Thomas. "Ruthenium Catalyzed Direct Asymmetric Reductive Amination of Simple Aliphatic Ketones Using Ammonium Iodide and Hydrogen". supporting information. . Retrieved 2020/07/14.