2-Hydrazino-4-methylpyridine

Base Information

• Chemical Name: 2-Hydrazino-4-methylpyridine
• CAS No.: 4931-00-4
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933990090
• European Community (EC) Number: 836-128-6
• DSSTox Substance ID: DTXSID70483169
• Wikidata: Q82320260
• Mol file: 4931-00-4.mol

Synonyms:2-hydrazino-4-methylpyridine;4931-00-4;2-Hydrazinyl-4-methylpyridine;(4-methylpyridin-2-yl)hydrazine;1-(4-METHYLPYRIDIN-2-YL)HYDRAZINE;4-methyl-2-pyridylhydrazine;MFCD09863246;SCHEMBL960313;SCHEMBL23074739;DTXSID70483169;FNFPJUDYICAQSZ-UHFFFAOYSA-N;AKOS005173504;PS-5633;SB75674;BL010278;SY067182;AM20061806;BB 0261993;CS-0186649;FT-0683382;EN300-56339

Chemical Property of 2-Hydrazino-4-methylpyridine

Chemical Property:

• Melting Point: 74 °C
• Boiling Point: 88-89 °C(Press: 0.02 Torr)
• PKA: 9.85±0.70(Predicted)
• PSA: 50.94000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 1.44890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydrazino-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)NN

Technology Process of 2-Hydrazino-4-methylpyridine

There total 4 articles about 2-Hydrazino-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-4-picoline (3678-62-4) → 2-hydrazinyl-4-methylpyridine (4931-00-4)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 32h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.7b02020

Reference yield: 73.0%

2-fluoro-4-methylpyridine (461-87-0) → 2-hydrazinyl-4-methylpyridine (4931-00-4)

Guidance literature:

With hydrazine; at 150 ℃; for 0.166667h; Inert atmosphere;

Reference yield:

picoline (108-89-4) → 2-hydrazinyl-4-methylpyridine (4931-00-4)

Guidance literature:

With sodium hydrazide; hydrazine; at 110 ℃;

upstream raw materials:

picoline

2-fluoro-4-methylpyridine

2-chloro-4-picoline

Downstream raw materials:

7‐methyl‐2H,3H‐[1,2,4]triazolo[4,3‐a]pyridin‐3‐one

7-methyl-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine

7-Methyl-s-triazolo<4,3-a>pyridin

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". Paragraph 0630-0632. . Retrieved 2020/01/04.
• 2、 Xu, Yan,Young, Michael C.,Dong, Guangbin. "Catalytic Coupling between Unactivated Aliphatic C-H Bonds and Alkynes via a Metal-Hydride Pathway". supporting information. p. 5716 - 5719. Retrieved 2017/05/04.