4-Methoxy-3,5-dimethylphenol

Base Information

• Chemical Name: 4-Methoxy-3,5-dimethylphenol
• CAS No.: 4962-29-2
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• DSSTox Substance ID: DTXSID20349160
• Nikkaji Number: J859.888F
• Wikidata: Q82124243
• Mol file: 4962-29-2.mol

Synonyms:4-methoxy-3,5-dimethylphenol;4962-29-2;3,5-Dimethyl-4-methoxyphenol;phenol, 4-methoxy-3,5-dimethyl-;2,6-Dimethyl-4-hydroxyanisole;SCHEMBL9768514;4-Methoxy-3,5-dimethyl-phenol;SCHEMBL11139442;DTXSID20349160;AT19450;BS-32481;A1-06961

Chemical Property of 4-Methoxy-3,5-dimethylphenol

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1OC)C)O

Technology Process of 4-Methoxy-3,5-dimethylphenol

There total 12 articles about 4-Methoxy-3,5-dimethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-methoxy-1,3-dimethylbenzene (1004-66-6) → 4-methoxy-3,5-dimethylphenol (4962-29-2)

Guidance literature:

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; trifluoroacetic anhydride; at 80 ℃; for 1.5h;

Reference yield: 44.0%

methanol (67-56-1) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 4-methoxy-3,5-dimethylphenol (4962-29-2)

Guidance literature:

methanol; 3,5-Dimethylphenol; With [bis(acetoxy)iodo]benzene; at 0 - 20 ℃; for 0.533333h; Inert atmosphere;

With zinc; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c6ob00073h

Reference yield:

C17H20O3 → C17H18O + 4-methoxy-3,5-dimethylphenol (4962-29-2) + acetophenone (98-86-2)

Guidance literature:

With sulfuric acid; In acetonitrile; at 0 ℃; for 0.0166667h;

DOI:10.1039/b804055a

upstream raw materials:

dimethyl sulfate

3,5-Dimethylphenol

4-hydroxy-3,5-dimethylphenyl acetate

5-(2,6-dimethyl-phenoxy)-2-methoxy-1,3-dimethyl-benzene

Downstream raw materials:

3,5-Diiod-4-(4-methoxy-3,5-dimethyl-phenoxy)-phenylessigsaeure

3,5-Diiod-4-(4-methoxy-3,5-dimethyl-phenoxy)-phenylessigsaeure-methylester

4-amino-2,6-dimethylanisole

2-methoxy-1,3-dimethyl-5-nitrosobenzene

Refernces

• 1、 Zhu, Runqing,Sun, Qianqian,Li, Jing,Li, Luohao,Gao, Qinghe,Wang, Yakun,Fang, Lizhen. "Para -Selective hydroxylation of alkyl aryl ethers". supporting information. p. 13190 - 13193. Retrieved 2021/12/16.
• 2、 Blum, Travis R.,Zhu, Ye,Nordeen, Sarah A.,Yoon, Tehshik P.. "Photocatalytic synthesis of dihydrobenzofurans by oxidative [3+2] cycloaddition of phenols". . p. 11056 - 11059. Retrieved 2015/03/30.