Benzenemethanol, a-(1-bromoethyl)-

Base Information

• Chemical Name: Benzenemethanol, a-(1-bromoethyl)-
• CAS No.: 4962-45-2
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Mol file: 4962-45-2.mol

Synonyms:

Chemical Property of Benzenemethanol, a-(1-bromoethyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-(1-bromoethyl)-

There total 27 articles about Benzenemethanol, a-(1-bromoethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-propenylbenzene (873-66-5) → (1-bromoethyl)benzyl bromide (1196-45-8) + 2-bromo-1-phenyl-propan-1-ol (4962-45-2) + 2-bromo-1-phenyl-1-propanone (2114-00-3)

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; potassium bromide; ammonium metavanadate; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.02.074

Reference yield: 75.0%

cis-1-phenyl-1-propylene (766-90-5) → (1SR,2RS)-2-bromo-1-phenyl-1-propanol (4962-45-2,21759-57-9,21759-58-0,52130-04-8,52147-51-0)

Guidance literature:

cis-1-phenyl-1-propylene; With trifluorormethanesulfonic acid; tetrabutylammomium bromide; tetrabutylammonium tetrafluoroborate; dimethyl sulfoxide; In dichloromethane; at -78 - 0 ℃; for 1h; Inert atmosphere; Electrochemical reaction;

With sodium hydroxide; In dichloromethane; water; at 25 ℃; for 1h; regioselective reaction; Inert atmosphere; Electrochemical reaction;

DOI:10.3762/bjoc.11.27

Reference yield: 74.0%

1-propenylbenzene (873-66-5) → rac-(1S,2R)-2-bromo-1-phenyl-1-propan-1-ol (4962-45-2,21759-57-9,21759-58-0,52130-04-8,52147-51-0)

Guidance literature:

With water; hydrogen bromide; In acetonitrile; diastereoselective reaction; Electrolysis; Flow reactor;

DOI:10.1039/d1ob01302e

upstream raw materials:

1-phenylpropene

(1-bromoethyl)benzyl bromide

acetone

2-bromo-1-phenyl-1-propanone

Downstream raw materials:

(1RS,2RS)-1-acetoxy-2-bromo-1-phenyl-propane

(1RS,2RS)-1-hydroxy-1-phenyl-propane-2-sulfonic acid ; sodium-salt

cis-1-phenylpropene oxide

(+/-)-pseudoisoephedrine

Refernces

• 1、 Seitz, Jakob,Wirth, Thomas. "Electrochemical bromofunctionalization of alkenes in a flow reactor". supporting information. p. 6892 - 6896. Retrieved 2021/08/20.
• 2、 Dong, Jia Jia,Fernández-Fueyo, Elena,Li, Jingbo,Guo, Zheng,Renirie, Rokus,Wever, Ron,Hollmann, Frank. "Halofunctionalization of alkenes by vanadium chloroperoxidase from: Curvularia inaequalis". supporting information. p. 6207 - 6210. Retrieved 2017/07/10.