Pentafluoropropionic anhydride

Base Information

• Chemical Name: Pentafluoropropionic anhydride
• CAS No.: 356-42-3
• Molecular Formula: C6F10O3
• Molecular Weight: 310.048
• Hs Code.: 29159000
• European Community (EC) Number: 206-604-2
• NSC Number: 174167
• UNII: 0LFE7U11O5
• DSSTox Substance ID: DTXSID70870515
• Nikkaji Number: J208.859B
• Wikidata: Q27236944
• Mol file: 356-42-3.mol

Synonyms:2,2,3,3,3-pentafluoropropanoyl 2,2,3,3,3-pentafluoropropanoate;pentafluoropropanoic anhydride;pentafluoropropionic acid anhydride;pentafluoropropionic anhydride;perfluoropropionic anhydride;PFPAH

Chemical Property of Pentafluoropropionic anhydride

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 129mmHg at 25°C
• Melting Point: -43 °C
• Refractive Index: 1.3
• Boiling Point: 70.506 °C at 760 mmHg
• Flash Point: -6.44 °C
• PSA: 43.37000
• Density: 1.696 g/cm³
• LogP: 2.45140
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 4
• Exact Mass: 309.96877548
• Heavy Atom Count: 19
• Complexity: 342

Purity/Quality:

Pentafluoropropionic anhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-14
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Acid Anhydrides, Other
• Canonical SMILES: C(=O)(C(C(F)(F)F)(F)F)OC(=O)C(C(F)(F)F)(F)F
• Uses: Perfluoropropionic anhydride used in a GC-MS analysis of stereoisomer content of synthetic peptides.1 Also used in a GC-MS detection method for synephrine in dietary supplements.2 Pentafluoropropionic anhydride act as a derivatising agent of amines and alcohols. It is used in the in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluid, as derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detection and in simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography. Pentafluoropropionic anhydride was used:in preparation of halogenated derivatives of phenolic acids, required for determination of some biologically important acids in cerebrospinal fluidas derivatization reagent in detection of 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain by GC-multiple ion detectionin simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography

Technology Process of Pentafluoropropionic anhydride

There total 5 articles about Pentafluoropropionic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2,3,3,3-pentafluoropropionyl chloride (422-59-3) → 2,2,3,3,3-pentafluoropropanoic anhydride (356-42-3)

Guidance literature:

With dihydrogen peroxide; potassium hydroxide; In 1,3-dichloro-1,1,2,2,3-pentafluoropropane; water; at 0 - 5 ℃; Product distribution / selectivity;

Reference yield: 80.0%

pentafluoropropionic acid (422-64-0) → 2,2,3,3,3-pentafluoropropanoic anhydride (356-42-3)

Guidance literature:

With phosphorus pentoxide; Heating;

DOI:10.1039/P19920000461

Reference yield:

pentafluoropropionic acid (422-64-0) → perfluorobutane (355-25-9) + 2,2,3,3,3-pentafluoropropanoic anhydride (356-42-3)

Guidance literature:

Reaktion des Silber-Salzes;

DOI:10.1021/ja01109a029 DOI:10.1039/jr9530001548

upstream raw materials:

pentafluoropropionic acid

bis(trifluoromethyl)phosphinous pentafluoropropionic anhydride

2,2,3,3,3-pentafluoropropionyl chloride

Downstream raw materials:

2,2,3,3,3-Pentafluoro-propionic acid 2-[methyl-(2,2,3,3,3-pentafluoro-propionyl)-amino]-1-[3-(2,2,3,3,3-pentafluoro-propionyloxy)-phenyl]-ethyl ester

2,2,3,3,3-Pentafluoro-propionic acid 2-(2,2,3,3,3-pentafluoro-propionylamino)-1-phenyl-ethyl ester

1,1,1,2,2-pentafluoropentan-3-one

ethyl Pentafluoropropionate

Refernces

• 1、 Biswas, Kshetra M.,Jackson, Anthony H.,Kobaisy, Mozaina M.,Shannon, Patrick V. R.. "Electrophilic Substitution in Indoles. Part 18. Cyclisation of N-Acetyltryptamines". . p. 461 - 468. Retrieved 2007/10/02.