Technology Process of Phosphonic acid, [2-hydroxy-4-phenyl-1-(phenylmethyl)butyl]-,
1,1-dimethylethyl methyl ester
There total 3 articles about Phosphonic acid, [2-hydroxy-4-phenyl-1-(phenylmethyl)butyl]-,
1,1-dimethylethyl methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenethyl-phosphonic acid tert-butyl ester methyl ester;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
3-phenyl-propionaldehyde;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
ammonium chloride;
In
tetrahydrofuran; water;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/jo026834c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 62 percent / CH2Cl2; cyclohexane / 16 h
2.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
2.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
2.3: 53 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
n-butyllithium;
In
tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/jo026834c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: BHT; HCl / dioxane / 3 h / 50 °C
2.1: 62 percent / CH2Cl2; cyclohexane / 16 h
3.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.25 h / -78 °C
3.2: tetrahydrofuran; various solvent(s) / 1 h / -78 °C
3.3: 53 percent / NH4Cl / tetrahydrofuran; various solvent(s); H2O / -78 - 20 °C
With
hydrogenchloride; n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane;
DOI:10.1021/jo026834c
