8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate

Base Information

• Chemical Name: 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate
• CAS No.: 32795-47-4
• Deprecated CAS: 98644-14-5
• Molecular Formula: C₄H₄O₄*C₁₆H₁₈N₂
• Molecular Weight: 354.406
• Mol file: 32795-47-4.mol

Synonyms:Merital AM;Alival (antidepressant);CCRIS 1914;(+-)-Nomifensine hydrogen maleate;EINECS 251-223-7;NSC 289114;C16H18N2.C4H4O4;8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate;UNII-76S8CUH5MR;AKOS024456897;LS-85808;ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-8-AMINO-2-METHYL-4-PHENYL-, MALEATE

Chemical Property of 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate

Chemical Property:

• Vapor Pressure: 8.6E-06mmHg at 25°C
• Melting Point: 199-201°
• Boiling Point: 378.4°Cat760mmHg
• Flash Point: 164°C
• PSA: 103.86000
• Density: 1.114g/cm³
• LogP: 3.07700
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 354.15795719
• Heavy Atom Count: 26
• Complexity: 402

Purity/Quality:

98%,99%, ^*data from raw suppliers

NomifensineMaleicAcidSalt ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[NH+]1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=CC(=O)[O-])C(=O)O
• Isomeric SMILES: C[NH+]1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=C\C(=O)[O-])\C(=O)O
• Uses: Antidepressant;Dopamine uptake inhibitor Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.
• Therapeutic Function: Psychostimulant

Technology Process of 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate

There total 1 articles about 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ nomifensine maleate (24524-90-1,32795-47-4,70061-36-8,94532-56-6,94532-86-2,98461-26-8,98461-27-9,98644-14-5)

Guidance literature:

Reference yield: 55.0%

nomifensine maleate (24524-90-1,32795-47-4,70061-36-8,94532-56-6,94532-86-2,98461-26-8,98461-27-9,98644-14-5) + chloroformic acid ethyl ester (541-41-3) → 8-<(ethoxycarbonyl)amino>-4-phenyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

In benzene; for 3h; Heating;

DOI:10.1021/jm00157a012

Reference yield: 52.0%

nomifensine maleate (24524-90-1,32795-47-4,70061-36-8,94532-56-6,94532-86-2,98461-26-8,98461-27-9,98644-14-5) + 2-Chloroethyl chloroformate (627-11-2) → (2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-yl)-carbamic acid 2-chloro-ethyl ester

Guidance literature:

With pyridine; In benzene; for 3h; Heating;

DOI:10.1021/jm00157a012