3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE

Base Information

• Chemical Name: 3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE
• CAS No.: 1868-00-4
• Molecular Formula: C15H8F6O
• Molecular Weight: 318.218
• Hs Code.: 29147000
• Mol file: 1868-00-4.mol

Synonyms:Benzophenone,3,3'-bis(trifluoromethyl)- (7CI,8CI);3,3'-Bis(trifluoromethyl)benzophenone;3,3'-Ditrifluoromethylbenzophenone;Bis(3-trifluoromethylphenyl) ketone;

Chemical Property of 3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE

Chemical Property:

• Appearance/Colour: yellow crystal powder
• Melting Point: 100-102 °C(lit.)
• Boiling Point: 328.6 °C at 760 mmHg
• Flash Point: 126 °C
• PSA: 17.07000
• Density: 1.356 g/cm³
• LogP: 4.95520
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,3'-Bis(trifluoromethyl)benzophenone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE

There total 15 articles about 3,3'-BIS(TRIFLUOROMETHYL)BENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-Ethoxycarbonylpiperidine (5325-94-0) + 3-(trifluoromethyl)phenyllithium (368-49-0) → 3,3'-bis(trifluoromethyl)benzophenone (1868-00-4)

Guidance literature:

In diethyl ether; a) RT, 30 min, b) reflux, 30 min;

Reference yield: 70.0%

oxalyl dichloride (79-37-8) + tris(3-trifluoro-methylphenyl)bismuthane (121899-80-7) → 3,3'-bis(trifluoromethyl)benzophenone (1868-00-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.074

Reference yield: 69.0%

oxalyl dichloride (79-37-8) + C21H12F9In (1179318-32-1) → 3,3'-bis(trifluoromethyl)benzophenone (1868-00-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.07.074

upstream raw materials:

3-bromo-1-trifluoromethylbenzene

carbon dioxide

N-Ethoxycarbonylpiperidine

3-(trifluoromethyl)phenyllithium

Downstream raw materials:

3,3-bis[3-(trifluoromethyl)phenyl]-2-propenal

Refernces

• 1、 Rérat, Alice,Michon, Christophe,Agbossou-Niedercorn, Francine,Gosmini, Corinne. "Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate". . p. 4554 - 4560. Retrieved 2016/09/23.
• 2、 Novikov,Khlebnikov,Khistyaev,Magull. "Isomerization and 1,3-dipolar cycloaddition of gem-difluorinated NH-azomethine ylides in the reaction of difluorocarbene with diarylmethanimines". experimental part. p. 1070 - 1079. Retrieved 2009/08/08.