Acetic acid, trifluoro-, 3-oxo-4-(phenylmethyl)-2-morpholinyl ester

Base Information

• Chemical Name: Acetic acid, trifluoro-, 3-oxo-4-(phenylmethyl)-2-morpholinyl ester
• CAS No.: 502537-07-7
• Molecular Formula: C13H12F3NO4
• Molecular Weight: 303.238
• Mol file: 502537-07-7.mol

Synonyms:

Chemical Property of Acetic acid, trifluoro-, 3-oxo-4-(phenylmethyl)-2-morpholinyl ester

Chemical Property:

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid, trifluoro-, 3-oxo-4-(phenylmethyl)-2-morpholinyl ester

There total 3 articles about Acetic acid, trifluoro-, 3-oxo-4-(phenylmethyl)-2-morpholinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzylethanolamine (104-63-2) → trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester (502537-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / tetrahydrofuran; H₂O / 21 h / Heating

2: acetonitrile / 5 - 34 °C

In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja027458g

Reference yield:

4-benzyl-morpholine-2,3-dione (110843-90-8) → trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester (502537-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H₂O / 1 h / 10 °C

2: acetonitrile / 5 - 34 °C

With sodium hydroxide; dihydrogen peroxide; L-Selectride; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja027458g

Reference yield:

trifluoroacetic anhydride (407-25-0) + 4-benzyl-2-hydroxy-morpholin-3-one (287930-73-8) → trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester (502537-07-7)

Guidance literature:

In acetonitrile; at 5 - 34 ℃;

DOI:10.1021/ja027458g

upstream raw materials:

trifluoroacetic anhydride

4-benzyl-2-hydroxy-morpholin-3-one

4-benzyl-morpholine-2,3-dione

N-Benzylethanolamine

Downstream raw materials:

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

aprepitant

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Refernces