3-bromosenecioic acid

Base Information

• Chemical Name: 3-bromosenecioic acid
• CAS No.: 1578-14-9
• Molecular Formula: C5H7BrO2
• Molecular Weight: 179.013
• Hs Code.: 2916190090
• Mol file: 1578-14-9.mol

Synonyms:Crotonicacid, 2-bromo-3-methyl- (7CI,8CI);2-Bromo-3-methyl-2-butenoic acid;2-Bromo-3-methylcrotonic acid;

Chemical Property of 3-bromosenecioic acid

Chemical Property:

• Vapor Pressure: 0.0247mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 257.2 °C at 760 mmHg
• Flash Point: 109.4 °C
• PSA: 37.30000
• Density: 1.596 g/cm³
• LogP: 1.75980

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-3-methyl-2-butenoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromosenecioic acid

There total 12 articles about 3-bromosenecioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Methylbutenoic acid (541-47-9) → 2-bromo-3-methyl-crotonic acid (1578-14-9)

Guidance literature:

3-Methylbutenoic acid; With bromine; In dichloromethane; at 0 ℃; for 12h;

With piperidine; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

DOI:10.1021/acs.orglett.1c01888

Reference yield:

α,β-dibromo-β,β-dimethylpropionic acid (80573-34-8) → 2-bromo-3-methyl-crotonic acid (1578-14-9)

Guidance literature:

With sodium ethanolate;

Reference yield:

1,1,3-tribromo-3-methyl-butan-2-one (1578-05-8) → 2-bromo-3-methyl-crotonic acid (1578-14-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01164a092

upstream raw materials:

3-bromo-4-methyl-pent-3-en-2-one

1,1,3-tribromo-3-methyl-butan-2-one

α,β-dibromo-β,β-dimethylpropionic acid

sodium ethanolate

Downstream raw materials:

methyl 2-bromo-3-methylbut-2-enoate

3-Methyl-2-methoxy-2-butenoic acid

2-methoxy-3-methyl-but-3-enoic acid

(E)-4-hydroxy-3-methylbut-2-enoic acid

Refernces

• 1、 Koebrich, G,Heinemann, H,Zuendorf, W. "-". . p. 565 - 584. Retrieved 1967.
• 2、 Cardillo, Giuliana,Fabbroni, Serena,Gentilucci, Luca,Perciaccante, Rossana,Tolomelli, Alessandra. "α-Bromo-β,γ-unsaturated ketenes for the synthesis of α-benzylamino-β,γ-unsaturated acids". . p. 593 - 601. Retrieved 2007/10/03.