4-Fluorophenyl acrylate

Base Information

• Chemical Name: 4-Fluorophenyl acrylate
• CAS No.: 50663-22-4
• Molecular Formula: C9H7FO2
• Molecular Weight: 166.152
• DSSTox Substance ID: DTXSID901310657
• Mol file: 50663-22-4.mol

Synonyms:4-fluorophenyl acrylate;50663-22-4;4-Fluorophenyl 2-propenoate;SCHEMBL2975869;QVQUMFLLXDVPJN-UHFFFAOYSA-N;DTXSID901310657

Chemical Property of 4-Fluorophenyl acrylate

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.04300762
• Heavy Atom Count: 12
• Complexity: 171

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC(=O)OC1=CC=C(C=C1)F

Technology Process of 4-Fluorophenyl acrylate

There total 2 articles about 4-Fluorophenyl acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Fluorophenol (371-41-5) + acryloyl chloride (814-68-6,25189-84-8) → 4-fluorophenyl acrylate (50663-22-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;

DOI:10.1039/d1ob02227j

Reference yield:

→ 4-fluorophenyl acrylate (50663-22-4)

Guidance literature:

Reference yield: 74.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + 4-fluorophenyl acrylate (50663-22-4) → 4-fluorophenyl 2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)acetate

Guidance literature:

With iron(III) sulfate hydrate; palladium dichloride; In water; acetonitrile; at 45 ℃; for 36h; regioselective reaction;

DOI:10.1039/d1ob02227j

upstream raw materials:

4-Fluorophenol

acryloyl chloride

Downstream raw materials:

3-phenyl-3-hydroxy-2-methylene-propanoic acid p-fluorophenyl ester

6-fluoro-4-chromanone

(R)-4-fluorophenyl 4-nitro-4-(phenylsulfonyl)pentanoate

Refernces

• 1、 -. "Materials and methods for the treatment of gastroesophageal reflux disease". . . Retrieved 2008/06/13.