2-(1H-pyrrol-1-yl)pyrazine

Base Information

• Chemical Name: 2-(1H-pyrrol-1-yl)pyrazine
• CAS No.: 50966-75-1
• Molecular Formula: C8H7N3
• Molecular Weight: 145.16100
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID701311104
• Nikkaji Number: J2.544.334I
• Mol file: 50966-75-1.mol

Synonyms:2-(1H-pyrrol-1-yl)pyrazine;50966-75-1;2-pyrrol-1-ylpyrazine;2-Pyrrol-1-yl-pyrazine;N-(2-Pyrazinyl)pyrrole;Bionet2_000495;SCHEMBL977966;2-(1H-Pyrrole-1-yl)pyrazine;DTXSID701311104;HMS1365G11;BBL020799;MFCD01443653;STK893489;AKOS000674899;CCG-321787;2-(1H-Pyrrol-1-yl)pyrazine, AldrichCPR;CS-0315901;6N-039

Chemical Property of 2-(1H-pyrrol-1-yl)pyrazine

Chemical Property:

• Melting Point: 84 °C
• PSA: 30.71000
• LogP: 1.26730
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 145.063997236
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

2-(1H-pyrrol-1-yl)pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN(C=C1)C2=NC=CN=C2

Technology Process of 2-(1H-pyrrol-1-yl)pyrazine

There total 4 articles about 2-(1H-pyrrol-1-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 2-Aminopyrazine (5049-61-6) → 2-N-pyrrolylpyrazine (50966-75-1)

Guidance literature:

In water; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2009.06.079

Reference yield: 90.0%

2-chloropyrazin (14508-49-7) + pyrrole (109-97-7,30604-81-0) → 2-N-pyrrolylpyrazine (50966-75-1)

Guidance literature:

With copper(l) iodide; N-hydroxyphthalimide; sodium methylate; In dimethyl sulfoxide; at 110 ℃; for 24h;

DOI:10.1021/jo7015983

Reference yield: 80.0%

2,5-diethoxytetrahydrofurane (3320-90-9) + 3-aminopyrazinoic acid (5424-01-1) → 2-N-pyrrolylpyrazine (50966-75-1)

Guidance literature:

In acetic acid; Heating;

upstream raw materials:

2,5-diethoxytetrahydrofurane

3-aminopyrazinoic acid

2-chloropyrazin

pyrrole

Refernces

• 1、 Wilson, Matthew A.,Filzen, Gary,Welmaker, Gregory S.. "A microwave-assisted, green procedure for the synthesis of N-aryl sulfonyl and N-aryl pyrroles". experimental part. p. 4807 - 4809. Retrieved 2009/10/26.
• 2、 Laduree, Daniel,Kashef, Hussein El,Robba, Max. "SYNTHESIS OF 9H-PYRROLO-1,4-DIAZAINDOL-9-ONE". . p. 299 - 301. Retrieved 2007/10/02.