2-Naphthalenecarboxylic acid, 3-hydroxy-4-nitro-, methyl ester

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-4-nitro-, methyl ester
• CAS No.: 5394-81-0
• Molecular Formula: C12H9NO5
• Molecular Weight: 247.207
• Hs Code.: 2918199090
• Mol file: 5394-81-0.mol

Synonyms:3-Hydroxy-4-nitro-[2]naphthoesaeure-methylester;methyl 3-hydroxy-4-nitro-2-naphthoate;3-HYDROXY-4-NITRO-2-NAPHTHOIC ACID,METHYL ESTER;

Chemical Property of 2-Naphthalenecarboxylic acid, 3-hydroxy-4-nitro-, methyl ester

Chemical Property:

• Vapor Pressure: 9.89E-06mmHg at 25°C
• Boiling Point: 361.5°Cat760mmHg
• Flash Point: 172.4°C
• PSA: 92.35000
• Density: 1.439g/cm³
• LogP: 2.76340

Purity/Quality:

99%min ^*data from raw suppliers

Methyl3-hydroxy-4-nitro-2-naphthoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenecarboxylic acid, 3-hydroxy-4-nitro-, methyl ester

There total 1 articles about 2-Naphthalenecarboxylic acid, 3-hydroxy-4-nitro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-hydroxy-2-naphthoic acid methyl ester (883-99-8) → methyl 3-hydroxy-4-nitro-2-naphthoate (5394-81-0)

Guidance literature:

With sulfuric acid; nitric acid; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.2174/1570178611310050014

Reference yield: 37.0%

methyl 3-hydroxy-4-nitro-2-naphthoate (5394-81-0) → 1-amino-2-hydroxy-3-naphthoic acid methyl ester (104655-33-6)

Guidance literature:

With iron; ammonium chloride; In methanol; water; for 4h; Reflux;

DOI:10.2174/1570178611310050014

Reference yield:

methyl 3-hydroxy-4-nitro-2-naphthoate (5394-81-0) → benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5)

Guidance literature:

upstream raw materials:

3-hydroxy-2-naphthoic acid methyl ester

Downstream raw materials:

benzene-1,2-dicarboxylic acid

1-amino-2-hydroxy-3-naphthoic acid methyl ester

Refernces

• 1、 Xie, Fuchun,Li, Bingbing X.,Xiao, Xiangshu. "Synthesis and evaluation of an O-Aminated naphthol AS-E as a prodrug of CREB-mediated gene transcription inhibition". . p. 380 - 384. Retrieved 2013/07/26.