N-Methoxymethyl-N-methylformamide

Base Information

• Chemical Name: N-Methoxymethyl-N-methylformamide
• CAS No.: 5129-79-3
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• European Community (EC) Number: 610-646-0
• DSSTox Substance ID: DTXSID101295138
• Nikkaji Number: J1.492.116H
• Mol file: 5129-79-3.mol

Synonyms:N-Methoxymethyl-N-methylformamide;5129-79-3;N-(methoxymethyl)-N-methylformamide;SCHEMBL614881;Methoxymethyl(methyl)formamide #;DTXSID101295138;N-Methyl-N-(methoxymethyl)formamide

Chemical Property of N-Methoxymethyl-N-methylformamide

Chemical Property:

• Vapor Pressure: 0.403mmHg at 25°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.063328530
• Heavy Atom Count: 7
• Complexity: 55.7

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(COC)C=O

Technology Process of N-Methoxymethyl-N-methylformamide

There total 7 articles about N-Methoxymethyl-N-methylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

chloromethyl methyl ether (107-30-2) → N-methoxymethyl-N-methylformamide (5129-79-3)

Guidance literature:

N-Methylformamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

Reference yield:

milled wood lignin → 1,1,3,3-tetrachloropropanone (632-21-3) + N-methoxymethyl-N-methylformamide (5129-79-3) + N-methyl-N(2-methylpropyl)formamide + α-(1'-chloroethylidene)-β-(chloromethyl)-γ-butyrolactone + 2-methylphenyl aldehyde (529-20-4)

Guidance literature:

With O₄V^(3-)*Bi⁽³⁺⁾; In aq. buffer; pH=8.2; Electrochemical reaction; Irradiation;

DOI:10.1039/d0gc01521k

Reference yield:

methanol (67-56-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-methoxymethyl-N-methylformamide (5129-79-3)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; (electrolysis);

DOI:10.1016/0040-4020(72)80031-0

upstream raw materials:

methanol

N-formyloxymethyl-N-methylformamide

N-Methylformamide

chloromethyl methyl ether

Refernces

• 1、 Li, Weidong,Han, Yuling,Chen, Jianxin. "α-Alkoxycarbonyl-α-hydroxy secondary amides from a carbamoylsilane and α-ketoesters". . p. 5813 - 5819. Retrieved 2017/09/05.
• 2、 Eberson, Lennart. "Direct vs. Indirect Mechanisms in Organic Electrochemistry. Estimates of Activation Energies for Hydrogen Atom Transfer Processes of Relevance in Indirect Mechanisms Using the Bond Energy-Bond Order (BEBO) and Equibonding Methods". . p. 481 - 492. Retrieved 2007/10/02.