Isoquinoline, 3-phenyl-, 2-oxide

Base Information

• Chemical Name: Isoquinoline, 3-phenyl-, 2-oxide
• CAS No.: 51787-71-4
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Mol file: 51787-71-4.mol

Synonyms:

Chemical Property of Isoquinoline, 3-phenyl-, 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinoline, 3-phenyl-, 2-oxide

There total 16 articles about Isoquinoline, 3-phenyl-, 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-1-(2-(phenylethynyl)phenyl)ethanone O-methyl oxime (1140903-17-8) → 3-phenylisoquinoline 2-oxide (51787-71-4)

Guidance literature:

With Au(IMes)OTf; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-2008-1042936

Reference yield: 96.0%

2-phenylethynylbenzaldehyde oxime (106824-49-1) → 3-phenylisoquinoline 2-oxide (51787-71-4)

Guidance literature:

With C₂₁H₂₆AuN₂⁽¹⁺⁾*CF₃O₃S^(1-); at 20 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1055/s-0034-1379884

Reference yield: 89.0%

iodobenzene (591-50-4) + 3-carboxyisoquinoline N-oxide (103041-27-6) → 3-phenylisoquinoline 2-oxide (51787-71-4)

Guidance literature:

With potassium carbonate; tricyclohexylphosphine tetrafluoroborate; silver carbonate; palladium(II) bromide; In N,N-dimethyl-formamide; at 150 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.5b00475

upstream raw materials:

2-phenylethynylbenzaldehyde oxime

o-(phenylethynyl)benzaldehyde

phenylacetylene

ortho-bromobenzaldehyde

Downstream raw materials:

C₁₆H₁₀N₂

1-chloro-3-phenylisoquinoline

1-(4-tert-butylphenoxy)-3-phenylisoquinoline

1-phenoxy-3-phenylisoquinoline

Refernces

• 1、 Li, Huimin,Liao, Lihao,Zhao, Xiaodan. "Organoselenium-Catalyzed Aza-Wacker Reactions: Efficient Access to Isoquinolinium Imides and an Isoquinoline N -Oxide". supporting information. p. 1688 - 1692. Retrieved 2019/08/26.
• 2、 Yuan, Jin-Wei,Li, Wei-Jie,Xiao, Yong-Mei. "KMnO4-mediated direct C2-selective C?H arylation of quinoline N-oxides with aromatic hydrazines". . p. 179 - 186. Retrieved 2016/12/23.