Benzenepropanoyl chloride, 2-chloro-

Base Information

• Chemical Name: Benzenepropanoyl chloride, 2-chloro-
• CAS No.: 52085-97-9
• Molecular Formula: C9H8Cl2O
• Molecular Weight: 203.068
• Mol file: 52085-97-9.mol

Synonyms:3-(2-chlorophenyl) propanoyl chloride;3-(2-chloro-phenyl)-propionyl chloride;3-(2-chlorophenyl)propanoyl chloride;3-(2-Chlor-phenyl)-propionylchlorid;2-Chlor-hydrozimtsaeure-chlorid;o-Chlorhydrozimtsaeurechlorid;

Chemical Property of Benzenepropanoyl chloride, 2-chloro-

Chemical Property:

• PSA: 17.07000
• LogP: 3.03800

Purity/Quality:

95+% ^*data from raw suppliers

2-Chlorobenzenepropanoylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoyl chloride, 2-chloro-

There total 6 articles about Benzenepropanoyl chloride, 2-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(2-chlorophenyl)propanoic acid (1643-28-3) → 3-(2-chlorophenyl)propionyl chloride (52085-97-9)

Guidance literature:

With thionyl chloride; In tetrachloromethane; for 3h; Reflux;

Reference yield:

trans-2-chlorocinnamic acid (704-96-1,939-58-2) → 3-(2-chlorophenyl)propionyl chloride (52085-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 15 h / 20 °C / 760.05 Torr

2: thionyl chloride / tetrachloromethane / 3 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; In tetrachloromethane; ethyl acetate;

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 3-(2-chlorophenyl)propionyl chloride (52085-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium acetate / 4 h / 160 - 180 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 15 h / 20 °C / 760.05 Torr

3: thionyl chloride / tetrachloromethane / 3 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium acetate; In tetrachloromethane; ethyl acetate;

upstream raw materials:

3-(2-chlorophenyl)propanoic acid

trans-2-chlorocinnamic acid

2-chloro-benzaldehyde

oxalyl dichloride

Downstream raw materials:

2-(2-chlorophenyl)ethanamine

4-chloro-2,3-dihydro-1H-inden-1-one

2-(2-chloro-phenethyl)-3-hydroxy-[1,4]naphthoquinone

3-(2-chlorophenyl)-propionanilide

Refernces

• 1、 Gagnepain, Julien,Jeanmart, Stephane,Bonvalot, Damien,Jacob, Olivier,Lamberth, Clemens. "Synthesis of Conformationally Locked and C-Linked Analogues of Imidazole-Based Ketene Dithioacetal Fungicides". . p. 59 - 62. Retrieved 2019/01/04.
• 2、 Li, Shangda,Wang, Hang,Weng, Yunxiang,Li, Gang. "Carboxy Group as a Remote and Selective Chelating Group for C?H Activation of Arenes". supporting information. p. 18502 - 18507. Retrieved 2019/11/14.