Benazepril

Base Information Edit

Chemical Name:Benazepril
CAS No.:86541-75-5
Molecular Formula:C24H28N2O5
Molecular Weight:424.497
Hs Code.:
UNII:UDM7Q7QWP8
DSSTox Substance ID:DTXSID5022645
Nikkaji Number:J22.179A
Wikipedia:Benazepril
Wikidata:Q592802
NCI Thesaurus Code:C61645
RXCUI:18867
Pharos Ligand ID:ZFAJJB1KUW2L
Metabolomics Workbench ID:42879
ChEMBL ID:CHEMBL838
Mol file:86541-75-5.mol

Synonyms:1H-1-Benzazepine-1-aceticacid, 3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-,[S-(R*,R*)]-;Benapril;Briem;Cibacen;Cibacen WS;Cibacene;[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid;1H-1-benzazepine-1-acetic acid, 3-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-, (3S)-;acide [(3S)-3-{[(1S)-1-(éthoxycarbonyl)-3-phénylpropyl]amino}-2-oxo-2,3,4,5-tétrahydro-1H-1-benzazépin-1-yl]acétique;

Suppliers and Price of Benazepril

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BenazeprilFreeBase
2.5g
$ 1825.00

Medical Isotopes, Inc.
Benazepril
25 mg
$ 1500.00

CSNpharm
Benazepril
1g
$ 70.00

Crysdot
Benazepril 98+%
1g
$ 1129.00

Crysdot
Benazepril 98+%
250mg
$ 452.00

Crysdot
Benazepril 98+%
100mg
$ 282.00

ChemScene
Benazepril
500mg
$ 80.00

AvaChem
Benazepril
10g
$ 790.00

AvaChem
Benazepril
1g
$ 105.00

AvaChem
Benazepril
100mg
$ 45.00

Total 71 raw suppliers

Chemical Property of Benazepril Edit

Chemical Property:

Vapor Pressure:4.69E-20mmHg at 25°C
Melting Point:133-135°C(lit.)
Refractive Index:1.607
Boiling Point:691.2 °C at 760 mmHg
PKA:3.73±0.10(Predicted)
Flash Point:371.8 °C
PSA：95.94000
Density:1.26 g/cm³
LogP:3.02900
Storage Temp.:2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:424.19982200
Heavy Atom Count:31
Complexity:619

Purity/Quality:

98%min ^*data from raw suppliers

BenazeprilFreeBase ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Angiotensin-Converting Enzyme Inhibitors
Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
Isomeric SMILES:CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O
Recent ClinicalTrials:Preventing Microalbuminuria in Type 2 Diabetes
Recent EU Clinical Trials:A prospective, randomized, open label blinded end point probe trial to evaluate whether, at comparable blood pressure control, combined therapy with the ACE inhibitor Benazepril and the angiotensin II receptor blocker ARB Valsartan reduces progression to ESRD more effectively than Benazepril or Valsartan alone in high risk patients with type 2 diabetes and overt nephropathy VALID Study
Recent NIPH Clinical Trials:Therapeutic effects of direct renin inhibitor aliskiren added to AT1 receptor blocker in hypertensive patients with chronic kidney disease.
Uses Benazepril Free base is a non-sulfhydryl ACE inhibitor.
Therapeutic Function Antihypertensive

Technology Process of Benazepril

There total 3 articles about Benazepril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: