Benzeneacetic acid, a-hydroxy-, 1-methylethyl ester, (S)-

Base Information

• Chemical Name: Benzeneacetic acid, a-hydroxy-, 1-methylethyl ester, (S)-
• CAS No.: 53439-96-6
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol file: 53439-96-6.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-hydroxy-, 1-methylethyl ester, (S)-

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-hydroxy-, 1-methylethyl ester, (S)-

There total 93 articles about Benzeneacetic acid, a-hydroxy-, 1-methylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

isopropyl benzoylformate (31197-66-7) → (S)-α-hydroxyphenylacetic acid iso-propyl ester (53439-96-6)

Guidance literature:

With C₄₉H₇₆N₄O₄; aluminum tri-tert-butoxide; yttrium(III) trifluoromethanesulfonate; In chloroform; isopropyl alcohol; for 120h; enantioselective reaction; Molecular sieve;

DOI:10.1039/c7cc00273d

Reference yield: 93.0%

(S)-Mandelic acid (17199-29-0) + isopropyl alcohol (67-63-0,8013-70-5) → (S)-α-hydroxyphenylacetic acid iso-propyl ester (53439-96-6)

Guidance literature:

With boric acid; at 20 ℃; for 24h; Reagent/catalyst; Temperature;

Reference yield: 84.0%

(S)-(-)-ethyl mandelate (13704-09-1) + isopropyl alcohol (67-63-0,8013-70-5) → (S)-α-hydroxyphenylacetic acid iso-propyl ester (53439-96-6)

Guidance literature:

scandium tris(trifluoromethanesulfonate); for 72h; Heating;

DOI:10.1055/s-2007-967936

upstream raw materials:

isopropyl benzoylformate

(S)-Mandelic acid

isopropyl alcohol

triphenylbismuthane

Downstream raw materials:

C₁₃H₁₅ClO₄

(2-isopropoxy-2-oxo-(S)-1-phenylethyl) α-bromopropanoate

(2-isopropoxy-2-oxo-(S)-1-phenylethyl) α-bromophenylacetate

Refernces

• 1、 Hong, Yubiao,Jarrige, Lucie,Harms, Klaus,Meggers, Eric. "Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis". supporting information. p. 4569 - 4572. Retrieved 2019/03/19.
• 2、 Wu, Wangbin,Zou, Sijia,Lin, Lili,Ji, Jie,Zhang, Yuheng,Ma, Baiwei,Liu, Xiaohua,Feng, Xiaoming. "Catalytic asymmetric Meerwein-Ponndorf-Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex". supporting information. p. 3232 - 3235. Retrieved 2017/03/20.