Benzene, 1-(phenylsulfonyl)-4-(trifluoromethyl)-

Base Information

• Chemical Name: Benzene, 1-(phenylsulfonyl)-4-(trifluoromethyl)-
• CAS No.: 53451-93-7
• Molecular Formula: C13H9F3O2S
• Molecular Weight: 286.274
• Mol file: 53451-93-7.mol

Synonyms:

Chemical Property of Benzene, 1-(phenylsulfonyl)-4-(trifluoromethyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-(phenylsulfonyl)-4-(trifluoromethyl)-

There total 33 articles about Benzene, 1-(phenylsulfonyl)-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(trifluoromethyl)benzenesulfonyl azide (1152979-96-8) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-(trifluoromethyl)-4-(phenylsulfonyl)benzene (53451-93-7)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 25 ℃; for 3h; regiospecific reaction;

DOI:10.1021/acs.joc.8b03046

Reference yield: 91.0%

sodium benzenesulfonate (873-55-2) + potassium 4-(trifluoromethyl)phenyltrifluoroborate → 1-(trifluoromethyl)-4-(phenylsulfonyl)benzene (53451-93-7)

Guidance literature:

With copper(l) iodide; sodium acetate; In 1,2-dichloro-ethane; at 25 ℃; for 3h;

DOI:10.3184/174751914X13946468223913

Reference yield: 90.0%

triphenylbismuthane (603-33-8) + sodium 4-trifluoromethylbenzenesulfinate → 1-(trifluoromethyl)-4-(phenylsulfonyl)benzene (53451-93-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In toluene; at 80 ℃; for 15h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.organomet.1c00339

upstream raw materials:

phenyl 4-trifluoromethylphenyl sulfide

4-trifluoromethylphenylboronic acid

sodium benzenesulfonate

C₁₃H₉F₃N₂S

Refernces

• 1、 Thierry, Thibault,Pfund, Emmanuel,Lequeux, Thierry. "Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y". supporting information. p. 14826 - 14830. Retrieved 2021/10/01.
• 2、 Zhao, Fengqian,Wu, Xiao-Feng. "Sulfonylation of Bismuth Reagents with Sulfinates or SO2through BiIII/BiV Intermediates". supporting information. p. 2400 - 2404. Retrieved 2021/07/28.