ETHYL 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOATE

Base Information

• Chemical Name: ETHYL 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOATE
• CAS No.: 33280-93-2
• Molecular Formula: C9H17NO3S
• Molecular Weight: 219.305
• Hs Code.: 2930909090
• Mol file: 33280-93-2.mol

Synonyms:DL-Methionine,N-acetyl-, ethyl ester;Methionine, N-acetyl-, ethyl ester, DL- (8CI);DL-N-Acetylmethionine ethyl ester;N-Acetyl-DL-methionine ethyl ester;

Chemical Property of ETHYL 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOATE

Chemical Property:

• Vapor Pressure: 4.46E-06mmHg at 25°C
• Melting Point: 60-62 °C
• Refractive Index: 1.48
• Boiling Point: 383.2 °C at 760 mmHg
• Flash Point: 185.6 °C
• PSA: 80.70000
• Density: 1.091 g/cm³
• LogP: 1.19820

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-(acetylamino)-4-(methylthio)butanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOATE

There total 2 articles about ETHYL 2-(ACETYLAMINO)-4-(METHYLSULFANYL)BUTANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

acetamide (60-35-5) + 3-(methylsulfenyl)propanal (3268-49-3) → N-acetyl-DL-methionine (1115-47-5) + N-acetyl-DL-methionine ethyl ester (33280-93-2) + 1,3-bis(methylthio)propane (24949-35-7)

Guidance literature:

acetamide; carbon monoxide; With hydrogen; dicobalt octacarbonyl; In ethyl acetate; at 80 ℃; for 0.0833333h; under 97509.8 Torr;

3-(methylsulfenyl)propanal; In ethyl acetate; at 80 ℃; for 2.5h; under 97509.8 Torr; Product distribution / selectivity;

Reference yield: 89.9%

acetamide (60-35-5) + 3-(methylsulfenyl)propanal (3268-49-3) + carbon monoxide (201230-82-2) → N-acetyl-DL-methionine (1115-47-5) + N-acetyl-DL-methionine ethyl ester (33280-93-2) + 1,3-bis(methylthio)propane (24949-35-7)

Guidance literature:

acetamide; carbon monoxide; With hydrogen; dicobalt octacarbonyl; In ethyl acetate; at 80 ℃; for 0.0833333h; under 97509.8 Torr;

3-(methylsulfenyl)propanal; In ethyl acetate; for 2.5h; Product distribution / selectivity;

Reference yield: 59.0%

(E)-3-phenylpropenal (14371-10-9) + N-acetyl-DL-methionine ethyl ester (33280-93-2) → 1-Acetyl-5-hydroxy-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carboxylic acid ethyl ester (214220-96-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1246/cl.1998.943

upstream raw materials:

acetamide

3-(methylsulfenyl)propanal

carbon monoxide

Downstream raw materials:

N-[1-(N'-Isopropyl-hydrazinocarbonyl)-3-methylsulfanyl-propyl]-acetamide

1-Acetyl-5-hydroxy-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carboxylic acid ethyl ester

(S)-6-Benzyloxycarbonylamino-2-{[(2R,3S)-1-(3,3-diphenyl-propionyl)-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester

(S)-6-Benzyloxycarbonylamino-2-{[(2S,3R)-1-(3,3-diphenyl-propionyl)-2-(2-methylsulfanyl-ethyl)-3-phenyl-pyrrolidine-2-carbonyl]-amino}-hexanoic acid methyl ester

Refernces

• 1、 -. "PROCESS FOR PREPARING AMINO ACIDS USING THE AMIDOCARBONYLATION REACTION". Page/Page column 11-12. . Retrieved 2010/02/15.