Bacitracin zinc

Base Information

• Chemical Name: Bacitracin zinc
• CAS No.: 1405-89-6
• Deprecated CAS: 11031-59-7,73560-74-4,8028-08-8,8028-35-1,8058-81-9,92528-87-5
• Molecular Formula: C66H101N17O16SZn
• Molecular Weight: 1486.07
• Hs Code.: 29419090
• European Community (EC) Number: 614-244-6
• NCI Thesaurus Code: C28857
• RXCUI: 11417
• Mol file: 1405-89-6.mol

Synonyms:Albac;Ziba-RX;Caswell No. 909A;Neosporin Plus;Bacitracin zinc [USP];UNII-89Y4M234ES;EINECS 215-787-8;EPA Pesticide Chemical Code 006309;Bacitracin zinc [BAN];Bacitracin Zinc free sample;68038-70-0;SCHEMBL543112;89Y4M234ES;DRG-0121;AKOS015896384;FT-0622546;FT-0654564

Chemical Property of Bacitracin zinc

Chemical Property:

• Appearance/Colour: White to pale buff powder
• Melting Point: 250 °C (dec.)
• PSA: 561.83000
• LogP: 1.05220
• Storage Temp.: 2-8°C
• Solubility.: 10 mM HCl: 5 mg/mL, clear, faintly yellow-green
• Water Solubility.: 5.1 g/L (28 ºC)
• Hydrogen Bond Donor Count: 16
• Hydrogen Bond Acceptor Count: 21
• Rotatable Bond Count: 31
• Exact Mass: 1485.678083
• Heavy Atom Count: 101
• Complexity: 2950

Purity/Quality:

99% ^*data from raw suppliers

Bacitracin, Zinc ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB
• Canonical SMILES: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC3C=NC=N3)CC4=CC=CC=C4.[Zn]
• Recent NIPH Clinical Trials: The verification study for safety evaluation of excessive the test food ingestion in humans: a randomized, double-blind, placebo-controlled, parallel study
• Biological functions: Bacitracin zinc is a medicine applied to cuts and other skin wounds to help prevent infection. bacitracin is a germ-killing medicine called an antibiotic. peptide antibiotics have a strong antibacterial effect on the gram positive bacteria, also has antibacterial effect to a small number of Gram-negative bacteria, and the spiral and actinomycetes and resistant to penicillin resistant Staphylococcus aureus.The antibacterial mechanism inhibits for the formation of damage and bacterial cell wall. The bacterial cytoplasmic membrane can promote beneficial intestinal microbial growth, increased intestinal permeability, promote the absorption of nutrients. Mainly used to promote the growth of livestock and poultry, livestock and poultry as well as prevention and treatment of bacterial diarrhea caused by Treponema pig dysentery. Oral administration of bacitracin zinc is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility.
• Uses: 1. Bacitracin zinc is used as feed additive for promoting the growth of livestock and poultry, prevention and treatment of livestock and poultry bacterial diarrhea and dense helicoid is caused by blood dysentery. Oral administration of zinc bacitracin is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility. 2. Bacitracin zinc is a polypeptide antibiotic, against gram positive bacteria with a bactericidal effect, its mechanism is mainly inhibiting the synthesis of bacterial cell wall of bacteria, can also with sensitive bacteria cell membrane combined injury of cell membrane integrity, resulting in cells of the important materials in the outflow. Effectively inhibit gram positive bacteria and some gram negative bacteria; bacteria on resistance of bacitracin zinc slower, and other antibiotics without cross resistance.3. Peptide antibiotics, can inhibit the phosphorylation of pyrophosphate lipid, thereby inhibiting the synthesis of bacterial cell walls. Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
• Description: Bacitracin zinc is a zinc complex of bacitracin, a polypeptide produced by the growth of an organism of the licheniformis group of Bacillus subtilis. The main components are Bacitracin A, B1 and B2.Bacitracin zinc has antibiotic activity against a variety of Gram-positive bacteria including staphylococci. The zinc complex adds stability to the component, making bacitracin zinc more stable compared to bacitracin.
• Indications: Bacitracin zinc is composed of a group of polypeptides with antibiotic activity against a variety of Gram-positive bacteria including staphylococci. It is used in the treatment of local infections, mainly infections of the skin, ear and eye.