4-(4-chlorophenyl)-3-phenylbutan-2-amine

Base Information

• Chemical Name: 4-(4-chlorophenyl)-3-phenylbutan-2-amine
• CAS No.: 4814-11-3
• Molecular Formula: C16H18 Cl N . Cl H
• Molecular Weight: 259.7738
• Mol file: 4814-11-3.mol

Synonyms:Benzenepropanamine,4-chloro-a-methyl-b-phenyl-, hydrochloride (9CI);Phenethylamine, b-(p-chlorobenzyl)-a-methyl-, hydrochloride(7CI,8CI);N-[3-(4-Chlorophenyl)-2-phenyl-1-methylpropyl]amine hydrochloride;NSC 17144;NSC 18790;

Chemical Property of 4-(4-chlorophenyl)-3-phenylbutan-2-amine

Chemical Property:

• Vapor Pressure: 3.53E-05mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 353.7°Cat760mmHg
• Flash Point: 207.7°C
• Density: 1.116g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-chlorophenyl)-3-phenylbutan-2-amine

There total 12 articles about 4-(4-chlorophenyl)-3-phenylbutan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N-tert-butoxycarbonylamino)-4-(4-chlorophenyl)-3-phenylbutane (605679-93-4) → N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-amine hydrochloride (4814-11-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield:

N-methoxy-N-methyl-3-(4-chlorophenyl)-2-phenylpropanamide (605679-89-8) → N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-amine hydrochloride (4814-11-3)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / 0 °C

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3: triethylamine / ethyl acetate / 0.5 h / 0 °C

4: sodium azide / N,N-dimethyl-formamide / 1 h / 120 °C

5: hydrogen / platinum(IV) oxide / ethyl acetate / 24 h

6: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-(4-chlorophenyl)-3-phenyl-2-butanol (605679-90-1) → N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-amine hydrochloride (4814-11-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / ethyl acetate / 0.5 h / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 1 h / 120 °C

3: hydrogen / platinum(IV) oxide / ethyl acetate / 24 h

4: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2-(N-tert-butoxycarbonylamino)-4-(4-chlorophenyl)-3-phenylbutane

N-methoxy-N-methyl-3-(4-chlorophenyl)-2-phenylpropanamide

4-(4-chlorophenyl)-3-phenyl-2-butanol

2-azido-4-(4-chlorophenyl)-3-phenylbutane

Refernces

• 1、 -. "ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS". Page/Page column 43-44; 46-47. . Retrieved 2010/02/11.
• 2、 -. "SUBSTITUTED AMIDES ACTIVE AT THE CANNABINOID-1 RECEPTOR". Page 30. . Retrieved 2010/02/07.