Technology Process of Uridine,2',3'-dideoxy-2',3'-difluoro-5-methyl- (9CI)
There total 1 articles about Uridine,2',3'-dideoxy-2',3'-difluoro-5-methyl- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: 1.) pyridine, 2.) NaOH / 1.) 60 deg C, 18 h, 2.) dioxane-methanol-water, room temperature overnight, reflux 30 min
3: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h
4: 100 percent / NaOH / dioxane
5: 64 percent / diethylaminosulfur trifluoride / CH2Cl2 / 8 h / Ambient temperature
6: 60 percent / 80percent acetic acid / 45 h / 60 °C
With
pyridine; sodium hydroxide; diethylamino-sulfur trifluoride; acetic acid; trifluoromethanesulfonic acid anhydride;
In
1,4-dioxane; dichloromethane;