2-(4-Pyridinyl)-2-oxazoline

Base Information

• Chemical Name: 2-(4-Pyridinyl)-2-oxazoline
• CAS No.: 54120-68-2
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Hs Code.: 2934999090
• Mol file: 54120-68-2.mol

Synonyms:2-(pyridin-4-yl)-4,5-dihydrooxazole;4-(4,5-dihydro-oxazol-2-yl)-pyridine;4-(4,5-Dihydro-oxazol-2-yl)-pyridin;2-(4-pyridyl)-3,4-dihydrooxazole;2-(3-Pyridyl)-2-oxazoline;Pyridine,4-(4,5-dihydro-2-oxazolyl);4-(2-oxazolinyl)pyridine;2-(4-pyridyl)-4,5-dihydrooxazole;4-(4,5-Dihydro-1,3-oxazol-2-yl)pyridine;

Chemical Property of 2-(4-Pyridinyl)-2-oxazoline

Chemical Property:

• Melting Point: 103-105 °C
• Boiling Point: 285.6±13.0 °C(Predicted)
• PKA: 4.16±0.10(Predicted)
• PSA: 34.48000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 0.29400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Pyridinyl)-2-oxazoline

There total 1 articles about 2-(4-Pyridinyl)-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

3-(2-iodobenzyl)-2-(pyridin-4-yl)oxazolidine (1256490-82-0) → 2-(pyridine-4-yl)-4,5-dihydrooxazole (54120-68-2) + 3,3'-dibenzyl-2,2'-di(pyridin-4-yl)-2,2'-bioxazolidine

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c0ob00205d

Reference yield: 84.0%

2-(pyridine-4-yl)-4,5-dihydrooxazole (54120-68-2) → N-(2-nitroxyethyl)isonicotinamide (65141-47-1)

Guidance literature:

With tert.-butylnitrite; oxygen; In 1,4-dioxane; at 60 ℃; Sealed tube; Green chemistry;

DOI:10.1039/c7gc02682j

upstream raw materials:

3-(2-iodobenzyl)-2-(pyridin-4-yl)oxazolidine

Downstream raw materials:

N-(2-nitroxyethyl)isonicotinamide

Refernces