1-Naphthohydrazide

Base Information

• Chemical Name: 1-Naphthohydrazide
• CAS No.: 43038-45-5
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Hs Code.: 2928000090
• European Community (EC) Number: 256-054-2
• NSC Number: 23046
• DSSTox Substance ID: DTXSID30195650
• Nikkaji Number: J308.229F
• Wikidata: Q83068669
• Mol file: 43038-45-5.mol

Synonyms:1-Naphthohydrazide;43038-45-5;1-Naphthhydrazide;naphthalene-1-carbohydrazide;1-Naphthalenecarbohydrazide;1-Naphthalenecarboxylic acid, hydrazide;1-naphthoic hydrazide;.alpha.-Naphthoylhydrazine;naphthalene-1-carboxylic acid hydrazide;NSC23046;EINECS 256-054-2;NSC 23046;AI3-30723;1-Naphthohydrazide #;naphthoic acid hydrazide;naphthoic acid hydrazone;Alpha-naphthoic-hydrazide;1-Naphthoic acid hydrazide;1--Naphthoic acid hydrazide;alpha-naphthoic acid hydrazide;SCHEMBL145153;DTXSID30195650;BBL025775;MFCD00016804;NSC-23046;STK501298;AKOS000153955;SB86276;DS-18049;BB 0240677;CS-0149900;FT-0608109;FT-0608110;N0776;EN300-84409;T72470;A872768;AN-068/40186625;2-PHENYL-QUINOLINE-4-CARBOXYLICACIDMETHYLESTER;Z58982025

Chemical Property of 1-Naphthohydrazide

Chemical Property:

• Melting Point: 166-168 °C
• Refractive Index: 1.672
• PKA: 12.65±0.30(Predicted)
• PSA: 55.12000
• Density: 1.232 g/cm³
• LogP: 2.53450
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 217

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Naphthohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2C(=O)NN

Technology Process of 1-Naphthohydrazide

There total 7 articles about 1-Naphthohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-1-naphthamide → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + 1-naphthohydrazide (43038-45-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield: 92.0%

ethyl 1-naphthoate (3007-97-4) → 1-naphthohydrazide (43038-45-5)

Guidance literature:

With hydrazine; In ethanol; for 16h; Reflux; Inert atmosphere;

DOI:10.1021/jm1008852

Reference yield: 88.0%

1-naphthalenecarboxylic acid (86-55-5) → 1-naphthohydrazide (43038-45-5)

Guidance literature:

With acetic acid; acetic acid hydrazide; for 0.0833333h; Microwave irradiation;

upstream raw materials:

naphthalene-1-carbonic acid chloride

1-naphthalenecarboxylic acid

ethyl 1-naphthoate

methyl 1-naphthoate

Downstream raw materials:

2-(naphthalen-1-yl)-1,3,4-oxadiazole

1-α-Naphthoyl-2-β-naphthoyl-hydrazin

(E)-N’-(4-nitrobenzylidene)-1-naphthohydrazide

(E)-N’-(2-hydroxy-3-methoxybenzylidene)-1-naphthohydrazide

Refernces

• 1、 Baud, Damien,Bebrone, Carine,Becker, Katja,Benvenuti, Manuela,Cerboni, Giulia,Chelini, Giulia,Cutolo, Giuliano,De Luca, Filomena,Docquier, Jean-Denis,Feller, Georges,Fischer, Marina,Galleni, Moreno,Gavara, Laurent,Gresh, Nohad,Kwapien, Karolina,Legru, Alice,Mangani, Stefano,Mercuri, Paola,Pozzi, Cecilia,Sannio, Filomena,Sevaille, Laurent,Tanfoni, Silvia,Verdirosa, Federica,Berthomieu, Dorothée,Bestgen, Beno?t,Frère, Jean-Marie,Hernandez, Jean-Fran?ois. "4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors". . . Retrieved 2020/09/16.
• 2、 Drozd, Monika,Ginalska, Grazyna,Karczmarzyk, Zbigniew,Kowalczuk, Dorota,Morawiak, Maja,Pitucha, Monika,Swatko-Ossor, Marta,Urbanczyk-Lipkowska, Zofia,Wysocki, Waldemar. "Synthesis and structural study of some N-acyl-4-allylsemicarbazides and the product of their cyclization with a potential antimicrobial activity". . . Retrieved 2020/06/21.