2-phenyl-1-(4-pyridinyl)ethanol

Base Information

• Chemical Name: 2-phenyl-1-(4-pyridinyl)ethanol
• CAS No.: 54813-58-0
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol file: 54813-58-0.mol

Synonyms:2-Phenyl-1-[4]pyridyl-aethanol;2-phenyl-1-[4]pyridyl-ethanol;2-Phenyl-1-(4-pyridyl)-aethanol;2-Phenyl-1-(4-pyridyl)-ethanol;1-pyridyl-2-phenylethanol;

Chemical Property of 2-phenyl-1-(4-pyridinyl)ethanol

Chemical Property:

• PSA: 33.12000
• LogP: 2.35770

Purity/Quality:

2-PHENYL-1-(PYRIDIN-4-YL)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-1-(4-pyridinyl)ethanol

There total 10 articles about 2-phenyl-1-(4-pyridinyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-4-(3-phenyloxiran-2-yl)pyridine → 2-phenyl-1-(pyridin-4-yl)ethanol (54813-58-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr; regioselective reaction;

DOI:10.1002/ejoc.200800992

Reference yield: 74.0%

pyridine-4-carbaldehyde (872-85-5) + benzyltrimethylsilane (770-09-2) → 2-phenyl-1-(pyridin-4-yl)ethanol (54813-58-0)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.05.078

Reference yield:

trans-4-styrylpyride (5097-93-8) → 4-(2-phenylethyl)pyridine (2116-64-5) + 2-phenyl-1-(pyridin-4-yl)ethanol (54813-58-0)

Guidance literature:

With sodium tetrahydroborate; magnesium(II) perchlorate; air; cobalt tetra-tert-butylphthalocyanine; In tetrahydrofuran; ethanol; at 20 ℃;

DOI:10.1016/j.mencom.2007.11.015

upstream raw materials:

pyridine-4-carbaldehyde

benzylmagnesium chloride

4-benzyloxymethylpyridine

trans-4-styrylpyride

Refernces

• 1、 Blasio, Nadia Di,Lopardo, Maria Teresa,Lupattelli, Paolo. "1,2-Diarylethanols by alternative regioselective reductive ring-opening of 2,3-diaryloxiranes". experimental part. p. 938 - 944. Retrieved 2009/07/19.
• 2、 Kalashnikov, Valery V.,Tomilova, Larisa G.. "Catalytic reduction of an α,β-disubstituted alkene with sodium borohydride in the presence of tetra-tert-butylphthalocyanine complexes". . p. 343 - 344. Retrieved 2008/04/05.