2-Iodobenzoic acid phenacyl ester

Base Information

• Chemical Name: 2-Iodobenzoic acid phenacyl ester
• CAS No.: 55153-31-6
• Molecular Formula: C15H11IO3
• Molecular Weight: 366.155
• Mol file: 55153-31-6.mol

Synonyms:

Chemical Property of 2-Iodobenzoic acid phenacyl ester

Chemical Property:

Purity/Quality:

2-IODOBENZOIC ACID PHENACYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Iodobenzoic acid phenacyl ester

There total 14 articles about 2-Iodobenzoic acid phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Iodobenzoic acid (88-67-5) + α-bromoacetophenone (70-11-1) → 2-oxo-2-phenylethyl 2-iodobenzoate (55153-31-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetone;

DOI:10.1021/acscatal.7b02117

Reference yield: 90.0%

1-Phenylethynyl-1H-1λ3-benzo[d][1,2]iodoxol-3-one → 2-oxo-2-phenylethyl 2-iodobenzoate (55153-31-6)

Guidance literature:

With water; sodium acetate; 1,3-bis(mesityl)imidazolium chloride; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 52.0%

2-phenyl-4(3H)-quinazolinone (1022-45-3) + 1-Phenylethynyl-1H-1λ3-benzo[d][1,2]iodoxol-3-one → 2-oxo-2-phenylethyl 2-iodobenzoate (55153-31-6)

Guidance literature:

With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In 1,2-dichloro-ethane; at 70 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.8b02738

upstream raw materials:

sodium ortho-iodobenzoate

α-bromoacetophenone

(E)-4-methoxy-N-[1-(pyridin-4-yl)ethylidene]aniline

1-hydroxy-1,2-benzodioxol-3-(1H)-one

Downstream raw materials:

2-Iodobenzoic acid

Refernces

• 1、 Rohokale, Rajendra S.,Kalshetti, Rupali G.,Ramana, Chepuri V.. "Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation". . p. 2951 - 2961. Retrieved 2019/02/26.
• 2、 Speckmeier, Elisabeth,Zeitler, Kirsten. "Desyl and phenacyl as versatile, photocatalytically cleavable protecting groups: A classic approach in a different (visible) light". . p. 6821 - 6826. Retrieved 2017/11/06.