NG-MONOMETHYL-D-ARGININE MONOACETATE

Base Information

• Chemical Name: NG-MONOMETHYL-D-ARGININE MONOACETATE
• CAS No.: 137694-74-7
• Molecular Formula: C₇H₁₆N₄O₂
• Molecular Weight: 188.23
• Mol file: 137694-74-7.mol

Synonyms:NG-Monomethyl-D-arginine

Chemical Property of NG-MONOMETHYL-D-ARGININE MONOACETATE

Chemical Property:

• Melting Point: 180-190 °C
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of NG-MONOMETHYL-D-ARGININE MONOACETATE

There total 16 articles about NG-MONOMETHYL-D-ARGININE MONOACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-benzyloxycarbonyl-L-ornithine (2640-58-6) → NMMA (17035-90-4,137694-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N NaOH / 192 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1080/00397919108020795

Reference yield:

N-α-carbobenzyloxy-NG-methyl-(L)-arginine (134810-05-2) → NMMA (17035-90-4,137694-74-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1080/00397919108020795

Reference yield:

(S)-2-Amino-5-{[1-phenyl-meth-(Z)-ylidene]-amino}-pentanoic acid (25693-00-9) → NMMA (17035-90-4,137694-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1N NaOH, 2.) 1N NaOH / 1.) -3 deg C, 2.) -3 deg C

2: 2N NaOH / 192 h / 20 °C

3: H₂ / 10percent Pd/C / methanol / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1080/00397919108020795

upstream raw materials:

N,S-dimethylisothiourea hydroiodide

L-ornithine hydrochloride

N-α-carbobenzyloxy-N^G-methyl-(L)-arginine

bromocyane

Refernces

• 1、 Zhang,Hershline,Dowd. "A highly efficient preparation of N(G)-methyl-L-arginine and N(G)-methyl-D-arginine". . p. 2789 - 2792. Retrieved 1994.
• 2、 Kennedy, Kevin J.,Simandan, Tiberiu L.,Dix, Thomas A.. "A facile route to cyclic and acyclic alkyl-arginines". . p. 741 - 746. Retrieved 2007/10/03.