2,2-Dimethyl-7-chloro-3-heptyne

Base Information

• Chemical Name: 2,2-Dimethyl-7-chloro-3-heptyne
• CAS No.: 55402-10-3
• Molecular Formula: C9H15Cl
• Molecular Weight: 158.66800
• Mol file: 55402-10-3.mol

Synonyms:7-chloro-2,2-dimethyl-hept-3-yne;3-Chloropropyl-tert.-butyl acetylen;

Chemical Property of 2,2-Dimethyl-7-chloro-3-heptyne

Chemical Property:

• PSA: 0.00000
• LogP: 3.05490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-7-chloro-3-heptyne

There total 3 articles about 2,2-Dimethyl-7-chloro-3-heptyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,3-Dimethylbut-1-yne (917-92-0) + 1-iodo-3-chloro-propane (6940-76-7) → 1-chloro-6,6-dimethylhept-4-yne (55402-10-3)

Guidance literature:

3,3-Dimethylbut-1-yne; With n-butyllithium; In tetrahydrofuran; hexane; at -15 - 20 ℃; for 2.66667h;

1-iodo-3-chloro-propane; In tetrahydrofuran; hexane; at 20 ℃; for 72h;

Reference yield: 75.0%

3-chloropropyl p-toluenesulfonate (632-02-0) + 3,3-Dimethylbut-1-yne (917-92-0) → 1-chloro-6,6-dimethylhept-4-yne (55402-10-3)

Guidance literature:

3,3-Dimethylbut-1-yne; With n-butyllithium; In tetrahydrofuran;

3-chloropropyl p-toluenesulfonate; With tert-butylamine hydrobromide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/ejic.200400851

Reference yield:

tertiary butyl chloride (507-20-0) + 1-chloro-4-pentyne (14267-92-6) → 1-chloro-6,6-dimethylhept-4-yne (55402-10-3)

Guidance literature:

Multistep reaction; (i) nBuLi, AlCl₃, (ii) /BRN= 1730872/, ClCH₂CH₂Cl;

DOI:10.1021/ja00858a035

upstream raw materials:

tertiary butyl chloride

1-chloro-4-pentyne

3-chloropropyl p-toluenesulfonate

3,3-Dimethylbut-1-yne

Refernces

• 1、 -. "SYNTHESIS OF CAPSAICIN DERIVATIVES". Page/Page column 35-36. . Retrieved 2021/09/26.