Phenylphosphonic acid methylphenyl ester

Base Information

• Chemical Name: Phenylphosphonic acid methylphenyl ester
• CAS No.: 55638-42-1
• Molecular Formula: C13H13O3P
• Molecular Weight: 248.21400
• Mol file: 55638-42-1.mol

Synonyms:Phenylphosphonsaeure-O-methyl-O'-phenylester;Phenylphosphonsaeure-methyl-phenylester;

Chemical Property of Phenylphosphonic acid methylphenyl ester

Chemical Property:

• PSA: 45.34000
• LogP: 3.23040

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenylphosphonic acid methylphenyl ester

There total 7 articles about Phenylphosphonic acid methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isopropyl methyl phenylphosphonate (61733-58-2) + phenol (108-95-2,27073-41-2) → Phenylphosphonic Acid Methyl Phenyl Ester (55638-42-1)

Guidance literature:

isopropyl methyl phenylphosphonate; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 0.166667h; Sealed tube;

phenol; In dichloromethane; for 0.5h; Sealed tube;

DOI:10.1002/anie.201802082

Reference yield: 84.0%

methanol (67-56-1) + Phenyl N,N-dimethylphenylphosphonoamidate (5467-93-6) → Phenylphosphonic Acid Methyl Phenyl Ester (55638-42-1)

Guidance literature:

With boron trifluoride methanol complex; 1) 0 deg C, 1h, 2) RT, overnight;

DOI:10.1021/jo00016a042

Reference yield: 81.0%

dimethyl phenylphosphonate (2240-41-7) + phenol (108-95-2,27073-41-2) → Phenylphosphonic Acid Methyl Phenyl Ester (55638-42-1)

Guidance literature:

dimethyl phenylphosphonate; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 0.166667h; Sealed tube;

phenol; In dichloromethane; at 20 ℃; for 0.5h; Sealed tube;

DOI:10.1002/anie.201802082

upstream raw materials:

methanol

Phenyl N,N-dimethylphenylphosphonoamidate

P,P-dichlorophenylphosphine oxide

phenol

Refernces

• 1、 Huang, Hai,Denne, Johanna,Yang, Chou-Hsun,Wang, Haobin,Kang, Jun Yong. "Direct Aryloxylation/Alkyloxylation of Dialkyl Phosphonates for the Synthesis of Mixed Phosphonates". supporting information. p. 6624 - 6628. Retrieved 2018/05/14.