Omeprazole magnesium

Base Information

• Chemical Name: Omeprazole magnesium
• CAS No.: 217087-09-7
• Molecular Formula: 2(C17H18N3O3S)^.Mg^.3(H2O)
• Molecular Weight: 767.17
• Hs Code.: 2933399090
• European Community (EC) Number: 620-470-6,627-029-7,630-398-7,669-839-3
• NCI Thesaurus Code: C29032,C65539,C66256
• RXCUI: 236486,283562,1294569
• Mol file: 217087-09-7.mol

Synonyms:Esomeprazole;Esomeprazole Magnesium;Esomeprazole Potassium;Esomeprazole Sodium;Esomeprazole Strontium;Esomeprazole Strontium Anhydrous;Nexium;Strontium, Esomeprazole

Chemical Property of Omeprazole magnesium

Chemical Property:

• Appearance/Colour: off-white powder
• Vapor Pressure: 2.35E-14mmHg at 25°C
• Melting Point: 184-189 °C (dec.)
• Boiling Point: 600 °C at 760 mmHg
• Flash Point: 316.7 °C
• PSA: 198.59000
• LogP: 6.90950
• Storage Temp.: -20°C Freezer
• Solubility.: Slightly soluble in water, soluble in methanol, practically insoluble in heptane.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 10
• Exact Mass: 712.1988169
• Heavy Atom Count: 49
• Complexity: 993

Purity/Quality:

99.5% ^*data from raw suppliers

Esomeprazole magnesium trihydrate European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
• Recent ClinicalTrials: High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
• Recent EU Clinical Trials: 'A Phase III Study to Assess the Efficacy and Safety of NEXIUM for Maintenance of Healing of Erosive Esophagitis in Pediatric Patients 1 to 11 Years of Age'
• Uses: S-Form of Omeprazole. Gastric proton-pump inhibitor esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy. Zollinger-Ellison syndrome Peptic ulcer, site unspecified Duodenal ulcer Gastric ulcer Gastro-oesophageal reflux disease Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications: Gastro-Oesophageal Reflux Disease (GORD): treatment of erosive reflux oesophagitis; long-term management of patients with healed oesophagitis to prevent relapse; symptomatic treatment of gastro-oesophageal reflux disease (GORD). In combination with appropriate antibiotics for: healing of duodenal ulcer associated with Helicobacter pylori; eradication of Helicobacter pylori in patients with active or healed peptic ulcer. Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy. Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy. Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk. Esomeprazole Magnesium Trihydrate is used in preparation of esomeprazole magnesium trihydrate.