3-BENZYLOXYBENZOIC ACID

Base Information

• Chemical Name: 3-BENZYLOXYBENZOIC ACID
• CAS No.: 69026-14-8
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 2918990090
• Mol file: 69026-14-8.mol

Synonyms:3-(benzyloxy)benzoic acid;3-(benzyloxy)benzoic acid (IM OCS);3-phenylmethoxybenzoate;

Chemical Property of 3-BENZYLOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.04E-07mmHg at 25°C
• Melting Point: 133-137 °C
• Refractive Index: 1.605
• Boiling Point: 408.8 °C at 760 mmHg
• Flash Point: 157.9 °C
• PSA: 46.53000
• Density: 1.222 g/cm³
• LogP: 2.96380
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

3-Benzyloxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Benzyloxybenzoic acid is used as a pharmaceutical intermediate.

Technology Process of 3-BENZYLOXYBENZOIC ACID

There total 19 articles about 3-BENZYLOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Benzyloxybenzaldehyde (1700-37-4) → 3-benzyloxybenzoic acid (69026-14-8)

Guidance literature:

With sodium hydroxide; silver(l) oxide; In water; at 90 ℃; for 1h;

DOI:10.1016/00404-0399(50)1178K-

Reference yield: 97.5%

methyl 3-(benzyloxy)benzoate (79678-37-8) → 3-benzyloxybenzoic acid (69026-14-8)

Guidance literature:

methyl 3-(benzyloxy)benzoate; With methanol; potassium hydroxide; at 20 ℃; for 18h;

With sulfuric acid; In water; for 0.5h;

Reference yield: 89.0%

benzyl chloride (100-44-7) + 3-Carboxyphenol (99-06-9) → 3-benzyloxybenzoic acid (69026-14-8)

Guidance literature:

benzyl chloride; 3-Carboxyphenol; With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃;

With sodium hydroxide; In methanol; water; at 60 ℃; for 5h;

DOI:10.1016/j.bmcl.2018.02.001

upstream raw materials:

benzyl bromide

3-Carboxyphenol

methyl 3-hydroxybenzoate

benzyl chloride

Downstream raw materials:

3-(benzyloxy)-N-methoxy-N-methylbenzamide

3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester

3-benzyloxy-benzoic acid 2,3-bis-hexadecanoyloxy-propyl ester

3-benzyloxy-benzoic acid 2,3-dihydroxy-propyl ester

Refernces

• 1、 -. "1, 2, 4 - Oxadiazole Nrf2 activator - tacrine split product as well as preparation method and application thereof". Paragraph 0019; 0040-0041; 0043. . Retrieved 2021/11/06.
• 2、 Hartmann, Markus,Huber, Jessica,Kramer, Jan S.,Heering, Jan,Pietsch, Larissa,Stark, Holger,Odadzic, Dalibor,Bischoff, Iris,Fürst, Robert,Schr?der, Martin,Akutsu, Masato,Chaikuad, Apirat,D?tsch, Volker,Knapp, Stefan,Biondi, Ricardo M.,Rogov, Vladimir V.,Proschak, Ewgenij. "Demonstrating Ligandability of the LC3A and LC3B Adapter Interface". . p. 3720 - 3746. Retrieved 2021/05/04.