Chemical Property of Norstictic acid
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Chemical Property:
- Vapor Pressure:1.49E-24mmHg at 25°C
- Boiling Point:764.2°Cat760mmHg
- Flash Point:283.7°C
- PSA:139.59000
- Density:1.714g/cm3
- LogP:2.01330
- XLogP3:2.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:1
- Exact Mass:372.04813196
- Heavy Atom Count:27
- Complexity:651
- Purity/Quality:
-
99% *data from raw suppliers
Norstictic Acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=C(C2=C1C(=O)OC3=C(O2)C4=C(C(=C3C)O)C(=O)OC4O)C=O)O
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Description
Norstictic acid is a lichen metabolite that has been found in R. farinacea and has antimicrobial and anticancer activities. It is active against A. hydrophilia, B. subtilis, L. monocytogenes, P. vulgaris, S. faecalis, C. albicans, and C. glabrata (MICs = 0.1-6.7 mM). Norstictic acid (1-100 μM) inhibits proliferation, migration, and invasion of MDA-MB-231 cells. In vivo, norstictic acid (15 mg/kg, i.p.) reduces tumor growth in an MDA-MB-231/GFP mouse xenograft model.