N-[6-[(4-Aminophenyl)thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester

Base Information

• Chemical Name: N-[6-[(4-Aminophenyl)thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester
• CAS No.: 56073-96-2
• Molecular Formula: C15H14N4O2S
• Molecular Weight: 314.368
• Hs Code.: 2933990090
• Mol file: 56073-96-2.mol

Synonyms:

Chemical Property of N-[6-[(4-Aminophenyl)thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester

Chemical Property:

• PSA: 121.82000
• Density: 1.449g/cm3
• LogP: 4.06940

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[6-[(4-Aminophenyl)thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester

There total 8 articles about N-[6-[(4-Aminophenyl)thio]-1H-benzimidazol-2-yl]-carbamic acidmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3,4,4'-triaminodiphenyl sulfide (125159-34-4) + calcium cyanamide (156-62-7) + methyl chloroformate (79-22-1) → methyl N-[5(6)-(4-aminophenylsulfanyl)benzimidazol-2-yl]carbamate (56073-96-2)

Guidance literature:

calcium cyanamide; methyl chloroformate; In water; at 38 - 41 ℃; for 1h;

3,4,4'-triaminodiphenyl sulfide; In water; acetic acid; isopropyl alcohol; for 6h; Heating;

DOI:10.1023/A:1022571831161

Reference yield: 80.0%

[5-(4-acetylamino-phenylsulfanyl)-1(3)H-benzoimidazol-2-yl]-carbamic acid methyl ester (56073-95-1) → methyl N-[5(6)-(4-aminophenylsulfanyl)benzimidazol-2-yl]carbamate (56073-96-2)

Guidance literature:

With hydrogenchloride; Heating;

Reference yield:

5-(4-acetamidothiophenoxy)-2-nitroaniline (56073-93-9) → methyl N-[5(6)-(4-aminophenylsulfanyl)benzimidazol-2-yl]carbamate (56073-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. Na₂S₂O₄ / ethanol / 2 h / Heating

2: ethanol / Heating

3: aq. HCl / 2 h / Heating

With hydrogenchloride; sodium dithionite; In ethanol;

DOI:10.1021/jm0611051

upstream raw materials:

[5-(4-acetylamino-phenylsulfanyl)-1⁽³⁾H-benzoimidazol-2-yl]-carbamic acid methyl ester

3,4,4'-triaminodiphenyl sulfide

calcium cyanamide

methyl chloroformate

Refernces

• 1、 -. "Chemical compounds". . . Retrieved 2008/06/13.
• 2、 Abuzar, Syed,Rao, K. V. B.,Sharma, Satyavan,Gupta, Suman,Katiyar, J. C.. "Syntheses and Anthelmintic Activity of 2-Substituted 5(6)-Arylthio- and 5(6)-Arylsulphono-benzimidazoles". . p. 178 - 181. Retrieved 2007/10/02.