(Methyl-phenyl-amino)-acetic acid ethyl ester

Base Information

• Chemical Name: (Methyl-phenyl-amino)-acetic acid ethyl ester
• CAS No.: 21911-74-0
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.246
• NSC Number: 102731
• DSSTox Substance ID: DTXSID70944508
• Nikkaji Number: J881.152K
• Mol file: 21911-74-0.mol

Synonyms:ethyl n-methyl-n-phenylglycinate;21911-74-0;(Methyl-phenyl-amino)-acetic acid ethyl ester;Glycine, N-methyl-N-phenyl-, ethyl ester;ethyl 2-(N-methylanilino)acetate;NSC102731;ethyl (methylanilino)acetate;NCIOpen2_001864;SCHEMBL557889;DTXSID70944508;MFCD11179766;N-Methyl-N-phenylglycine ethyl ester;AKOS009058406;NSC-102731;ETHYL 2-[METHYL(PHENYL)AMINO]ACETATE

Chemical Property of (Methyl-phenyl-amino)-acetic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.00411mmHg at 25°C
• Boiling Point: 279.1°Cat760mmHg
• Flash Point: 105.5°C
• Density: 1.071g/cm³
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CN(C)C1=CC=CC=C1

Technology Process of (Methyl-phenyl-amino)-acetic acid ethyl ester

There total 21 articles about (Methyl-phenyl-amino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-phenylglycine ethyl ester (2216-92-4) + methyl iodide (74-88-4) → (methyl-phenyl-amino)-acetic acid ethyl ester (21911-74-0)

Guidance literature:

In toluene; at 70 ℃; for 4h;

Reference yield: 99.0%

ethyl bromoacetate (105-36-2) + N-methylaniline (100-61-8) → (methyl-phenyl-amino)-acetic acid ethyl ester (21911-74-0)

Guidance literature:

With sodium carbonate; In ethanol; for 14h; Reflux;

DOI:10.1002/anie.201306543

Reference yield: 99.0%

diazoacetic acid ethyl ester (623-73-4) + N-methylaniline (100-61-8) → (methyl-phenyl-amino)-acetic acid ethyl ester (21911-74-0)

Guidance literature:

With porous-polymer-supported ruthenium(II)-phenyloxazoline complex catalyst; In dichloromethane; at 20 ℃; for 0.25h; Solvent; Inert atmosphere;

DOI:10.14233/ajchem.2017.20192

upstream raw materials:

chloroacetic acid ethyl ester

N,N-dimethyl-aniline

N-methylaniline

ethyl bromoacetate

Downstream raw materials:

2-(N-Methylaniline)acetamide

2-(N-methyl-N-phenylamino)acethydrazide

4-(N-methyl-anilino)-2-phenyl-acetoacetonitrile

Refernces

• 1、 Lei, Lin-Sheng,Wang, Bo-Wen,Jin, Da-Ping,Gao, Zhu-Peng,Huan-Liang,Wang, Shao-Hua,Xu, Xue-Tao,Zhang, Kun,Zhang, Xiao-Yun. "Al(OTf)3-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues≠". . p. 2870 - 2875. Retrieved 2020.
• 2、 Zhou, Cong,Li, Miao,Sun, Jianwei,Cheng, Jiang,Sun, Song. "Photoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams". supporting information. p. 2895 - 2899. Retrieved 2021/05/05.
• 3、 -. "ADDITIVE COMPOSITION FOR CULTURE MEDIUM, ADDITIVE COMPOUND FOR CULTURE MEDIUM, AND METHOD FOR CULTURE OF CELLS OR TISSUE USING SAME". Paragraph 0211-0212. . Retrieved 2020/06/15.